Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | APP | P05067 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | PHGDH | O43175 | 3/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22021627 | 0.83 | ACLY (0.51) | ACLYAPPKDM4ECYP2A6CHRM2 | |
| SCHEMBL22004389 | 0.83 | ACLY (0.48) | ACLYKMT2AAPPMEN1RXFP1 | |
| SCHEMBL22004137 | 0.80 | ACLY (0.52) | ACLYKMT2AAPPMEN1KDM4E | |
| SCHEMBL8942357 | 0.74 | KMT2A (0.66) | ACLYKMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL22004306 | 0.71 | ACLY (0.49) | ACLYKMT2AMEN1RXFP1KDM4E | |
| SCHEMBL7799883 | 0.71 | KMT2A (0.50) | ACLYKMT2AAPPMEN1RXFP1 | |
| SCHEMBL22004293 | 0.70 | ACLY (0.50) | ACLYRXFP1KDM4EMAPTTP53 | |
| SCHEMBL11554791 | 0.69 | APP (0.68) | ACLYKMT2AAPPMEN1KDM4E | |
| SCHEMBL22004157 | 0.69 | ACLY (0.49) | ACLYKMT2AMEN1RXFP1KDM4E | |
| SCHEMBL6492730 | 0.68 | HSD11B1 (0.50) | KMT2AMEN1RXFP1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200157076-A1 | ACLY INHIBITORS AND USES THEREOF | NIMBUS DISCOVERY, INC. | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200157076-A1 | ACLY INHIBITORS AND USES THEREOF | ACLY, ATP5ME, ATP5MG | ACLY 1/4885KMT2A 1976/4885APP 4262/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.