Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 3/20 | 0.41 |
| ▸ | ACLY | P53396 | 1/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | PHGDH | O43175 | 2/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8942357 | 0.89 | KMT2A (0.66) | KMT2ACYP19A1ACLYPHGDHMEN1 | |
| SCHEMBL11686956 | 0.88 | KMT2A (0.46) | KMT2ARXFP1CYP19A1USP2TP53 | |
| SCHEMBL22021620 | 0.87 | ACLY (0.50) | KMT2ACYP19A1ACLYPTGS2KDM4E | |
| SCHEMBL6928202 | 0.87 | RXFP1 (0.48) | KMT2ARXFP1CYP19A1ACLYAHR | |
| SCHEMBL22004394 | 0.86 | KCNH2 (0.48) | KMT2ARXFP1CYP19A1ACLYAHR | |
| SCHEMBL17199055 | 0.86 | BRPF1 (0.47) | KMT2ARXFP1CYP19A1USP2TP53 | |
| SCHEMBL22004113 | 0.85 | ACLY (0.60) | KMT2ARXFP1CYP19A1ACLYAHR | |
| SCHEMBL11658428 | 0.84 | KMT2A (0.73) | KMT2ACYP19A1USP2TP53MAPK1 | |
| SCHEMBL22004377 | 0.82 | ACLY (0.54) | KMT2AMAPK1ACLYHSD11B1MEN1 | |
| SCHEMBL28104193 | 0.82 | RXFP1 (0.43) | KMT2ARXFP1CYP19A1AHRPHGDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20010039286-A1 | 2-aryl indole derivatives and their use as therapeutic agents | DINNELL KEVIN (GB) | 2001-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010039286-A1 | 2-aryl indole derivatives and their use as therapeutic agents | IDO1, IDO2, CNR2 | KMT2A 2907/4885RXFP1 391/4885CYP19A1 1636/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.