Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | BTK | Q06187 | 6/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22008959 | 0.84 | NPC1 (0.45) | NPC1RAB9AMEN1KMT2ABTK | |
| SCHEMBL22010160 | 0.82 | L3MBTL1 (0.48) | NPC1RAB9AMEN1KMT2ABTK | |
| SCHEMBL22009060 | 0.78 | NPC1 (0.50) | NPC1RAB9AMEN1KMT2ABTK | |
| SCHEMBL8260140 | 0.75 | NPC1 (0.53) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL29546594 | 0.75 | NPC1 (0.56) | NPC1RAB9AMEN1KMT2ABTK | |
| SCHEMBL25714929 | 0.73 | KIT (0.51) | NPC1RAB9AMEN1KMT2ABTK | |
| SCHEMBL6940180 | 0.73 | RAB9A (1.00) | NPC1RAB9AMEN1KMT2AGRM5 | |
| SCHEMBL3365984 | 0.73 | RAB9A (0.83) | NPC1RAB9AMEN1KMT2AGRM5 | |
| SCHEMBL14654074 | 0.72 | BTK (0.64) | NPC1RAB9AMEN1KMT2ABTK | |
| SCHEMBL22902914 | 0.72 | BTK (0.58) | NPC1RAB9AMEN1KMT2ABTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3653626-A1 | NOVEL 1H-PYRAZOLOPYRIDINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | Daewoong Pharmaceutical Co., Ltd. (KR) | 2020-05-20 | — | — | EP | disclosed |