Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GHSR | Q92847 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.38 |
| ▸ | ARG1 | P05089 | 1/20 | 0.38 |
| ▸ | ARG2 | P78540 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17499930 | 0.83 | S1PR5 (0.50) | TSHRCYP2D6ALDH1A1MEN1LMNA | |
| SCHEMBL29287890 | 0.83 | S1PR5 (0.50) | TSHRCYP2D6ALDH1A1MEN1LMNA | |
| SCHEMBL17517700 | 0.80 | L3MBTL1 (0.48) | CYP2D6CYP3A4ALDH1A1MEN1KMT2A | |
| SCHEMBL20179770 | 0.75 | L3MBTL1 (0.46) | CYP2D6ALDH1A1S1PR1S1PR5FUCA1 | |
| SCHEMBL20179769 | 0.72 | ALDH1A1 (0.45) | TSHRCYP2D6CYP3A4ALDH1A1SIGMAR1 | |
| SCHEMBL16714529 | 0.72 | FUCA1 (0.53) | TSHRALDH1A1MEN1KMT2ASIGMAR1 | |
| SCHEMBL26009111 | 0.72 | ACHE (0.49) | TSHRCYP2D6MEN1LMNAKMT2A | |
| SCHEMBL15647532 | 0.72 | DRD4 (0.48) | TSHRCYP2D6CYP3A4ALDH1A1MEN1 | |
| SCHEMBL29797081 | 0.72 | ALDH1A1 (0.56) | TSHRCYP2D6CYP3A4ALDH1A1MEN1 | |
| SCHEMBL28554966 | 0.72 | S1PR5 (0.45) | TSHRCYP2D6CYP3A4ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10662203-B2 | Pyrido[2,3-b]indole compounds for the treatment and prophylaxis of bacterial infection | HOFFMANN-LA ROCHE INC. (US) | 2020-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10662203-B2 | Pyrido[2,3-b]indole compounds for the treatment and prophylaxis of bacterial infection | IDO1, IDO2, KYNU | TSHR 1054/4885CYP2D6 64/4885CYP3A4 263/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.