Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.40 |
| ▸ | PPID | Q08752 | 3/20 | 0.40 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | PPIB | P23284 | 1/20 | 0.40 |
| ▸ | PPIA | P62937 | 1/20 | 0.40 |
| ▸ | PPIG | Q13427 | 1/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.37 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | SI | P14410 | 1/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11038014 | 0.83 | GAA (0.45) | GAAEPHX2PPIDPPIBPPIA | |
| SCHEMBL22172283 | 0.79 | KMT2A (0.41) | OPRM1SLC22A1SLC6A4ADRA1AOPRD1 | |
| SCHEMBL580416 | 0.75 | EPHX2 (0.43) | GAAEPHX2PPIDPPIBPPIA | |
| SCHEMBL2607180 | 0.75 | OPRM1 (0.54) | OPRM1SLC22A1SLC6A4ADRA1AOPRD1 | |
| Iodide SCHEMBL30309825 | 0.74 | OPRM1 (0.53) | OPRM1SLC22A1SLC6A4ADRA1AOPRD1 | |
| SCHEMBL10053026 | 0.73 | GAA (0.49) | GAAMGAMSIMGAM2 | |
| SCHEMBL20069764 | 0.73 | JAK2 (0.42) | — | |
| SCHEMBL15232250 | 0.72 | OPRM1 (0.44) | GAAOPRM1SLC22A1SLC6A4ADRA1A | |
| SCHEMBL20069677 | 0.71 | CYP2C19 (0.46) | — | |
| SCHEMBL18390115 | 0.71 | RET (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020099882-A1 | HETEROCYCLIC SPIRO-COMPOUNDS AS AM2 RECEPTOR INHIBITORS | THE UNIVERSITY OF SHEFFIELD (GB) | 2020-05-22 | — | — | WO | disclosed |