Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | TACR1 | P25103 | 3/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | STS | P08842 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22605145 | 1.00 | ACHE (0.43) | ACHETACR1NR1H2NR1H3CCR5 | |
| SCHEMBL23654053 | 1.00 | ACHE (0.43) | ACHETACR1NR1H2NR1H3CCR5 | |
| SCHEMBL6785103 | 0.86 | NR1H2 (0.47) | ACHENR1H2NR1H3JAK2JAK1 | |
| SCHEMBL16064467 | 0.81 | CCR5 (0.52) | CCR5JAK2JAK1GPR119STS | |
| SCHEMBL18495417 | 0.81 | CCR5 (0.52) | CCR5JAK2JAK1GPR119STS | |
| SCHEMBL2381394 | 0.79 | AGTR2 (0.48) | NR1H2NR1H3CCR5JAK2JAK1 | |
| SCHEMBL1983287 | 0.79 | AGTR2 (0.48) | NR1H2NR1H3CCR5JAK2JAK1 | |
| SCHEMBL1984795 | 0.79 | AGTR2 (0.48) | NR1H2NR1H3CCR5JAK2JAK1 | |
| SCHEMBL22010802 | 0.78 | SLC18A3 (0.43) | NR1H2NR1H3CCR5JAK2JAK1 | |
| SCHEMBL22605146 | 0.78 | SLC18A3 (0.43) | NR1H2NR1H3CCR5JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10662203-B2 | Pyrido[2,3-b]indole compounds for the treatment and prophylaxis of bacterial infection | HOFFMANN-LA ROCHE INC. (US) | 2020-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10662203-B2 | Pyrido[2,3-b]indole compounds for the treatment and prophylaxis of bacterial infection | IDO1, IDO2, KYNU | ACHE 1155/4885TACR1 152/4885NR1H2 2258/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.