Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22011828 | 0.79 | HSD11B1 (0.43) | POLBALDH1A1 | |
| SCHEMBL1381443 | 0.71 | CA2 (0.65) | ENPP2GRIN2B | |
| SCHEMBL2376239 | 0.71 | ENPP2 (0.72) | ENPP2 | |
| Hydrochloric Acid SCHEMBL14482763 | 0.69 | CA2 (0.63) | ENPP2GRIN2B | |
| SCHEMBL1818606 | 0.69 | PRSS1 (0.58) | ENPP2ALDH1A1GRIN2B | |
| SCHEMBL6096079 | 0.69 | CA2 (0.64) | ENPP2ALDH1A1 | |
| SCHEMBL22013020 | 0.69 | POLB (0.36) | POLBALDH1A1 | |
| SCHEMBL4327234 | 0.68 | AKR1C3 (0.51) | ENPP2ALDH1A1CYP1A2 | |
| Hydrochloric Acid SCHEMBL4176794 | 0.68 | PRSS1 (0.56) | ENPP2GRIN2B | |
| Carbamic Acid SCHEMBL11786852 | 0.68 | PTGS2 (0.57) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020102576-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |