Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25033947 | 0.89 | CA2 (0.36) | JAK2JAK1JAK3KDM4DACHE | |
| SCHEMBL25031530 | 0.88 | KDM4D (0.32) | KDM4D | |
| SCHEMBL22012725 | 0.79 | KDM4D (0.31) | JAK2JAK1JAK3KDM4D | |
| SCHEMBL31564466 | 0.79 | ADORA2A (0.35) | KDM4DACHE | |
| SCHEMBL31564374 | 0.79 | HSD11B1 (0.34) | KDM4DACHE | |
| SCHEMBL31563996 | 0.78 | HSD11B1 (0.33) | KDM4DACHE | |
| SCHEMBL31563832 | 0.78 | HSD11B1 (0.33) | KDM4DACHE | |
| SCHEMBL31564424 | 0.78 | PNMT (0.35) | KDM4DACHE | |
| SCHEMBL31563993 | 0.78 | HSD11B1 (0.33) | KDM4DACHE | |
| SCHEMBL31564435 | 0.77 | KCNQ2 (0.33) | KDM4DACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020102576-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |