Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 2/20 | 0.36 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.36 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.36 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | GCK | P35557 | 2/20 | 0.35 |
| ▸ | GCKR | Q14397 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.34 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | SLC22A11 | Q9NSA0 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | RORA | P35398 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24978417 | 0.82 | ALDH1A1 (0.43) | ALDH1A1MEN1MAPTKMT2AKDM4E | |
| SCHEMBL20692252 | 0.78 | CHRNA7 (0.42) | TP53ALDH1A1MAPTKMT2AKDM4E | |
| SCHEMBL20914740 | 0.77 | SMN1; SMN2 (0.51) | ALDH1A1KDM4EPOLBHTTSMN1; SMN2 | |
| SCHEMBL20692311 | 0.77 | ALDH1A1 (0.31) | ALDH1A1MEN1MAPTKMT2ARORA | |
| SCHEMBL25034031 | 0.77 | CA1 (0.35) | ABCC9ABCC8KCNJ11KCNJ8CYP2C9 | |
| SCHEMBL21971206 | 0.76 | GAA (0.52) | CYP2C9ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL22012922 | 0.75 | PSEN1 (0.32) | ALDH1A1MEN1MAPTKMT2ARORA | |
| SCHEMBL21893033 | 0.75 | ALDH1A1 (0.42) | ALDH1A1MEN1KMT2AKDM4EPOLB | |
| SCHEMBL10680402 | 0.74 | KEAP1 (0.48) | ALDH1A1MEN1KMT2APOLBGAA | |
| SCHEMBL29653635 | 0.74 | CA2 (0.46) | ABCC9ABCC8KCNJ11KCNJ8KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020102576-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |