Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | DHFR | P00374 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10148935 | 0.79 | SMN1; SMN2 (0.62) | SMN1; SMN2DHFRTSHRTDP1PKM | |
| SCHEMBL15625448 | 0.79 | EGFR (0.56) | SMN1; SMN2DHFRTSHRTDP1PKM | |
| SCHEMBL20914742 | 0.78 | SMN1; SMN2 (0.61) | SMN1; SMN2DHFRTSHRTDP1PKM | |
| SCHEMBL22012887 | 0.77 | ABCC9 (0.36) | SMN1; SMN2HTTPOLBALDH1A1KDM4E | |
| SCHEMBL29653635 | 0.74 | CA2 (0.46) | TSHRTDP1KDM4EPTGS2 | |
| SCHEMBL19508116 | 0.74 | CA2 (0.46) | TSHRTDP1KDM4EPTGS2 | |
| SCHEMBL22020764 | 0.73 | POLB (0.35) | SMN1; SMN2POLBKDM4E | |
| SCHEMBL7712520 | 0.73 | EPHX2 (0.69) | SMN1; SMN2DHFRTSHRTDP1PKM | |
| SCHEMBL19519045 | 0.72 | NLRP3 (0.66) | — | |
| SCHEMBL20914710 | 0.72 | PKM (0.53) | SMN1; SMN2DHFRTSHRTDP1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190119241-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS AG (CH) | 2019-04-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190119241-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NLRP1, NLRP3, NOD1 | SMN1; SMN2 2412/4885DHFR 3478/4885TSHR 4318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.