Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18573688 | 0.92 | CES2 (0.42) | CES2CES1RECQLSMN1; SMN2ALDH1A1 | |
| SCHEMBL18214886 | 0.92 | CES2 (0.42) | CES2CES1RECQLSMN1; SMN2ALDH1A1 | |
| SCHEMBL13543609 | 0.92 | CES2 (0.42) | CES2CES1RECQLSMN1; SMN2ALDH1A1 | |
| SCHEMBL65733 | 0.92 | CES2 (0.42) | CES2CES1RECQLSMN1; SMN2ALDH1A1 | |
| SCHEMBL3427267 | 0.92 | CES2 (0.42) | CES2CES1RECQLSMN1; SMN2ALDH1A1 | |
| SCHEMBL1341780 | 0.90 | CES2 (0.39) | CES2CES1RECQLSMN1; SMN2ALDH1A1 | |
| SCHEMBL1340689 | 0.90 | RIPK1 (0.35) | CES2CES1RECQLSMN1; SMN2ALDH1A1 | |
| SCHEMBL18994335 | 0.85 | CES2 (0.37) | CES2CES1RECQLSMN1; SMN2ALDH1A1 | |
| SCHEMBL9042000 | 0.83 | CES2 (0.33) | CES2CES1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL17115654 | 0.82 | SMN1; SMN2 (0.31) | CES2CES1RECQLSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10662171-B2 | Antidiabetic bicyclic compounds | MERCK SHARP & DOHME CORP. (US) | 2020-05-26 | — | — | US | disclosed |
| US-20170217920-A1 | ANTIDIABETIC BICYCLIC COMPOUNDS | MERCK SHARP & DOHME LLC | 2017-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10662171-B2 | Antidiabetic bicyclic compounds | GPR119, GPR65, GLP1R | CES2 1650/4885CES1 309/4885HSD11B1 522/4885 |
| US-20170217920-A1 | ANTIDIABETIC BICYCLIC COMPOUNDS | GPR119, GPR65, GLP1R | CES2 1650/4885CES1 309/4885HSD11B1 522/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.