Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 2/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
| ▸ | GPR6 | P46095 | 1/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.30 |
| ▸ | CDK9 | P50750 | 1/20 | 0.30 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.30 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29325037 | 0.95 | MPO (0.39) | MPOLRRK2NLRP3IRAK4MAP3K14 | |
| SCHEMBL20828397 | 0.88 | ALOX5 (0.36) | LRRK2ALOX5ALOX5APFEN1KAT2B | |
| SCHEMBL22421102 | 0.78 | NLRP3 (0.39) | MPONLRP3IRAK4MAP3K14ALOX5 | |
| SCHEMBL22421101 | 0.78 | MPO (0.36) | MPONLRP3IRAK4MAP3K14ALOX5 | |
| SCHEMBL20939390 | 0.77 | MPO (0.38) | MPONLRP3IRAK4CCNT1CDK9 | |
| SCHEMBL21646647 | 0.74 | MPO (0.38) | MPONLRP3 | |
| SCHEMBL31710359 | 0.74 | MPO (0.38) | MPONLRP3IRAK4 | |
| SCHEMBL23762679 | 0.73 | MPO (0.35) | MPONLRP3CCNT1CDK9 | |
| SCHEMBL22020551 | 0.73 | SMPD3 (0.36) | MPONLRP3 | |
| SCHEMBL22019996 | 0.73 | MPO (0.35) | MPONLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020102574-A1 | THE COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |