Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 2/20 | 0.36 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | LDHA | P00338 | 1/20 | 0.34 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29325037 | 0.82 | MPO (0.39) | MPONLRP3IRAK4LDHAMAP3K14 | |
| SCHEMBL22421102 | 0.79 | NLRP3 (0.39) | MPONLRP3IRAK4LDHAMAP3K14 | |
| SCHEMBL22014590 | 0.78 | MPO (0.35) | MPONLRP3IRAK4MAP3K14CCNT1 | |
| SCHEMBL2054538 | 0.73 | MPO (0.42) | MPONLRP3IRAK4LDHACCNT1 | |
| SCHEMBL31728149 | 0.73 | LDHA (0.46) | NLRP3IRAK4LDHACCNT1CDK9 | |
| SCHEMBL22421096 | 0.73 | MAP3K14 (0.35) | MAP3K14PDE4APDE4BPDE4C | |
| SCHEMBL20828397 | 0.71 | ALOX5 (0.36) | ALOX5ALOX5APFEN1 | |
| SCHEMBL30431300 | 0.70 | MPO (0.40) | MPONLRP3IRAK4LDHAHDAC1 | |
| SCHEMBL20939452 | 0.69 | MPO (0.42) | MPONLRP3IRAK4LDHACCNT1 | |
| SCHEMBL19431919 | 0.69 | MPO (0.42) | MPONLRP3IRAK4LDHACCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3478673-B1 | CYANOINDOLINE DERIVATIVES AS NIK INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-09-16 | — | — | EP | disclosed |