SCHEMBL22014610

SCHEMBL22014610

COC(=O)CC[n+]1cc(-c2ccncn2)sn1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.35
AAK1 Q2M2I8 1/20 0.34
PRKACA P17612 1/20 0.33
ROCK1 Q13464 1/20 0.33
ALDH1A1 P00352 2/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
NOX1 Q9Y5S8 1/20 0.32
MAPT P10636 2/20 0.32
CCNT1 O60563 1/20 0.32
CCNA2 P20248 1/20 0.32
CDK2 P24941 1/20 0.32
CDK9 P50750 1/20 0.32
CCNA1 P78396 1/20 0.32
CDK5 Q00535 1/20 0.32
CDK5R1 Q15078 1/20 0.32
KLKB1 P03952 1/20 0.32
GABRA5 P31644 1/20 0.31
P2RX7 Q99572 1/20 0.31
CCNC P24863 1/20 0.31
CDK8 P49336 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22015071 0.85 TBXA2R (0.34) CYP3A4P2RX7CYP2D6HTTKMT2A
SCHEMBL22015234 0.79 ALDH1A1 (0.39) ALDH1A1SMN1; SMN2MAPTRPS6KB2LMNA
SCHEMBL22015899 0.78 NPC1 (0.36) ALDH1A1SMN1; SMN2LMNA
SCHEMBL22340702 0.75 CYP2D6 (0.43) CYP3A4AAK1PRKACAROCK1ALDH1A1
SCHEMBL22340676 0.67 CYP2D6 (0.43) CYP3A4AAK1PRKACAROCK1ALDH1A1
SCHEMBL20753603 0.67 CYP2D6 (0.38) CYP3A4AAK1PRKACAROCK1ALDH1A1
SCHEMBL22020526 0.66 HDAC4 (0.34) ALDH1A1SMN1; SMN2MAPTLMNAHTT
SCHEMBL22014606 0.65 ALDH1A1 (0.38) ALDH1A1SMN1; SMN2RPS6KB2LMNAKMT2A
SCHEMBL17204708 0.65 KDM4E (0.45) CYP3A4PRKACAROCK1ALDH1A1MAPT
SCHEMBL22015230 0.63 ALDH1A1 (0.36) CYP3A4ALDH1A1SMN1; SMN2CTNNB1WNT3A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020099407-A1 HERBICIDAL COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2020-05-22 WO disclosed