Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 9/20 | 0.34 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.33 |
| ▸ | TDP2 | O95551 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2197850 | 0.92 | JAK2 (0.36) | AXLMAPK1TDP2CYP2C9ADRA1A | |
| SCHEMBL2197237 | 0.90 | MAPK1 (0.34) | MAPK1MAPK3CYP2C9ADRA1AHRH1 | |
| SCHEMBL2177542 | 0.85 | ABCB1 (0.42) | — | |
| SCHEMBL2201496 | 0.83 | MGLL (0.40) | AXLMAPK1CYP2C9ADRA1AHRH1 | |
| SCHEMBL2197877 | 0.81 | JAK2 (0.34) | AXLMAPK1CYP2C9ADRA1AHRH1 | |
| SCHEMBL2180605 | 0.80 | SLC2A1 (0.41) | — | |
| SCHEMBL2197233 | 0.77 | DGAT1 (0.42) | MAPK1CYP2C9ADRA1AHRH1KDR | |
| SCHEMBL2196065 | 0.77 | ALPL (0.38) | MAPK1CYP2C9ADRA1AHRH1 | |
| SCHEMBL2179479 | 0.76 | ABCB1 (0.41) | — | |
| SCHEMBL2198202 | 0.76 | JAK2 (0.36) | MAPK1TDP2CRBNKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519500-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | Piramal Healthcare Ltd. (IN) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011080718-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2011-07-07 | — | — | WO | disclosed |