SCHEMBL22015460

SCHEMBL22015460

CC(C)c1ccc(N(c2ccc(C#N)cc2)c2ccc(C(C)C)cc2)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 2/20 0.42
ALDH1A1 P00352 2/20 0.41
PANK3 Q9H999 1/20 0.40
CYP19A1 P11511 7/20 0.39
ERBB2 P04626 1/20 0.38
ENPP2 Q13822 1/20 0.38
CHRNB2 P17787 1/20 0.37
CHRNB4 P30926 1/20 0.37
CHRNA3 P32297 1/20 0.37
CHRNA4 P43681 1/20 0.37
S1PR1 P21453 1/20 0.37
CA12 O43570 1/20 0.37
CA2 P00918 1/20 0.37
CA3 P07451 1/20 0.37
CA6 P23280 1/20 0.37
CA9 Q16790 1/20 0.37
CA14 Q9ULX7 1/20 0.37
GRIA1 P42261 1/20 0.36
GRIA2 P42262 1/20 0.36
GRIA3 P42263 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15223124 0.90 PTGS1 (0.41) CYP2A6ALDH1A1PANK3KDM4ELMNA
SCHEMBL87339 0.87 CYP2A6 (0.52) CYP2A6ALDH1A1PANK3CYP19A1ERBB2
SCHEMBL20800817 0.86 CYP2A6 (0.40) CYP2A6ALDH1A1PANK3CYP19A1ERBB2
SCHEMBL15235254 0.83 ALDH1A1 (0.39) ALDH1A1PANK3KDM4ELMNAGAA
SCHEMBL995812 0.82 CA2 (0.50) CYP2A6ALDH1A1ENPP2CA12CA2
SCHEMBL12922764 0.82 TYR (0.44) ALDH1A1KDM4ELMNACYP3A4CYP2C19
SCHEMBL18805967 0.82 TYR (0.44) ALDH1A1KDM4ELMNACYP3A4CYP2C19
SCHEMBL12263202 0.81 MMP3 (0.52) CYP2A6ALDH1A1PANK3CYP19A1ERBB2
SCHEMBL10068521 0.80 RORC (0.37) ALDH1A1PANK3S1PR1CA2KDM4E
SCHEMBL179245 0.80 PANK3 (0.32) CYP2A6ALDH1A1PANK3S1PR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3024039-B1 ORGANIC SEMICONDUCTOR COMPOSITIONS SMARTKEM LTD (GB) 2020-05-20 EP disclosed