Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDIA6 | Q15084 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 6/20 | 0.52 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA6 | P23280 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8405351 | 0.85 | PDIA6 (0.53) | PDIA6CA2L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL1807162 | 0.85 | PDIA6 (0.53) | PDIA6CA2L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL7904621 | 0.85 | CA2 (0.52) | PDIA6CA2TRPA1ALDH1A1MEN1 | |
| SCHEMBL29469901 | 0.85 | CA2 (0.52) | PDIA6CA2TRPA1ALDH1A1MEN1 | |
| SCHEMBL4139997 | 0.84 | L3MBTL1 (0.41) | PDIA6CA2TRPA1L3MBTL1ALDH1A1 | |
| SCHEMBL1807165 | 0.83 | PDIA6 (0.51) | PDIA6CA2L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL9174184 | 0.82 | CA2 (0.53) | PDIA6CA2TRPA1L3MBTL1ALDH1A1 | |
| SCHEMBL17922517 | 0.82 | L3MBTL1 (0.55) | CA2TRPA1L3MBTL1ALDH1A1MEN1 | |
| SCHEMBL1805243 | 0.81 | PDIA6 (0.50) | PDIA6CA2L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL1607447 | 0.81 | ESR2 (0.41) | CA2TRPA1L3MBTL1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020102574-A1 | THE COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |