Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 17/20 | 0.68 |
| ▸ | OPRL1 | P41146 | 17/20 | 0.68 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17438538 | 0.90 | OPRL1 (0.63) | OPRM1OPRL1OPRK1 | |
| SCHEMBL17447446 | 0.90 | OPRL1 (0.63) | OPRM1OPRL1OPRK1 | |
| SCHEMBL2834926 | 0.89 | OPRM1 (0.72) | OPRM1OPRL1OPRK1 | |
| Hydrochloric Acid SCHEMBL2331328 | 0.87 | OPRL1 (0.69) | OPRM1OPRL1OPRK1 | |
| SCHEMBL13050538 | 0.83 | OPRM1 (0.44) | OPRM1OPRL1OPRK1 | |
| SCHEMBL3413521 | 0.82 | OPRL1 (1.00) | OPRM1OPRL1OPRK1 | |
| SCHEMBL2202407 | 0.81 | OPRM1 (0.50) | OPRM1OPRL1OPRK1 | |
| SCHEMBL31566894 | 0.78 | OPRL1 (0.61) | OPRM1OPRL1OPRK1 | |
| Trifluoroacetic Acid SCHEMBL3404097 | 0.76 | OPRM1 (0.54) | OPRM1OPRL1OPRK1 | |
| SCHEMBL6249783 | 0.75 | OPRL1 (0.75) | OPRM1OPRL1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8278319-B2 | Substituted spiroamine compounds | GRUENENTHAL GMBH (DE) | 2012-10-02 | — | — | US | disclosed |
| EP-2344457-A1 | SUBSTITUTED SPIROAMINES | Grünenthal GmbH (DE) | 2011-07-20 | — | — | EP | disclosed |
| US-20100113417-A1 | Substituted Spiroamine Compounds | GRUENENTHAL GMBH (DE) | 2010-05-06 | — | — | US | disclosed |
| US-20100113417-A1 | Substituted Spiroamine Compounds | GRUENENTHAL GMBH (DE) | 2010-05-06 | — | — | US | disclosed |
| US-20100113417-A1 | Substituted Spiroamine Compounds | GRUENENTHAL GMBH (DE) | 2010-05-06 | — | — | US | disclosed |
| WO-2010049146-A1 | SUBSTITUTED SPIROAMINES | Grünenthal GmbH (DE) | 2010-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113417-A1 | Substituted Spiroamine Compounds | BDKRB1, BDKRB2, REN | OPRM1 82/4885OPRL1 12/4885OPRK1 27/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.