Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 17/20 | 0.54 |
| ▸ | OPRL1 | P41146 | 17/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2834926 | 0.85 | OPRM1 (0.72) | OPRM1OPRL1OPRK1 | |
| Hydrochloric Acid SCHEMBL2331328 | 0.84 | OPRL1 (0.69) | OPRM1OPRL1OPRK1 | |
| SCHEMBL4631671 | 0.80 | OPRM1 (0.73) | OPRM1OPRL1OPRK1 | |
| Trifluoroacetic Acid SCHEMBL3409375 | 0.79 | OPRM1 (0.52) | OPRM1OPRL1OPRK1 | |
| SCHEMBL7309717 | 0.78 | OPRM1 (0.53) | OPRM1OPRL1OPRK1 | |
| Hydrochloric Acid SCHEMBL7478467 | 0.77 | OPRM1 (0.69) | OPRM1OPRL1OPRK1 | |
| Hydrochloric Acid SCHEMBL7478459 | 0.77 | OPRM1 (0.69) | OPRM1OPRL1OPRK1 | |
| SCHEMBL7514792 | 0.77 | OPRM1 (0.56) | OPRM1OPRL1OPRK1 | |
| Trifluoroacetic Acid SCHEMBL16413809 | 0.76 | OPRM1 (0.50) | OPRM1OPRL1 | |
| SCHEMBL27458716 | 0.76 | OPRM1 (0.75) | OPRM1OPRL1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9206156-B2 | Substituted indole derivatives | Grünenthal GmbH (DE) | 2015-12-08 | — | — | US | disclosed |
| EP-2254883-B1 | SUBSTITUTED INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2014-11-26 | — | — | EP | disclosed |
| US-20130116283-A1 | Substituted indole derivatives | Grünenthal GmbH (DE) | 2013-05-09 | — | — | US | disclosed |
| EP-2254883-A1 | SUBSTITUTED INDOLE DERIVATIVES | Grünenthal GmbH (DE) | 2010-12-01 | — | — | EP | disclosed |
| WO-2009103552-A1 | SUBSTITUTED INDOLE DERIVATIVES | Grünenthal GmbH (DE) | 2009-08-27 | — | — | WO | disclosed |
| US-20090215828-A1 | Substituted indole derivatives | GRUNENTHAL GMBH (DE) | 2009-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215828-A1 | Substituted indole derivatives | IDO1, IDO2, TPH1 | OPRM1 30/4885OPRL1 25/4885OPRK1 6/4885 |
| US-20130116283-A1 | Substituted indole derivatives | IDO1, IDO2, TPH1 | OPRM1 30/4885OPRL1 25/4885OPRK1 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.