Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 4/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.41 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.41 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.41 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | NOS3 | P29474 | 2/20 | 0.41 |
| ▸ | NOS1 | P29475 | 2/20 | 0.41 |
| ▸ | NOS2 | P35228 | 2/20 | 0.41 |
| ▸ | BLM | P54132 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL415546 | 0.85 | ALDH1A1 (0.50) | KIF11CES2CES1ORAI1ORAI2 | |
| Fluoride SCHEMBL29094699 | 0.83 | ALDH1A1 (0.48) | KIF11CES2CES1ORAI1ORAI2 | |
| Alcohol SCHEMBL11320369 | 0.80 | ALDH1A1 (0.43) | ALDH1A1TSHR | |
| SCHEMBL1765830 | 0.78 | KIF11 (0.61) | KIF11ALDH1A1TSHR | |
| Trifluoromethylbenzene SCHEMBL14891620 | 0.76 | ALDH1A1 (0.70) | KIF11TRPV6ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL7594733 | 0.74 | SRD5A2 (0.68) | CES2CES1MEN1KMT2APTPN1 | |
| Alcohol SCHEMBL29154486 | 0.74 | MGLL (0.79) | KIF11CES2CES1ORAI1ORAI2 | |
| SCHEMBL7672068 | 0.73 | LTA4H (0.45) | KIF11ALDH1A1TSHR | |
| SCHEMBL8765728 | 0.71 | PDE2A (0.52) | KIF11CES2CES1ORAI1ORAI2 | |
| Alcohol SCHEMBL27497004 | 0.71 | SMN1; SMN2 (0.52) | KIF11CES2CES1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8247264-B2 | Transistor, method for manufacturing same, and semiconductor device comprising such transistor | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-08-21 | — | — | US | disclosed |
| US-7977149-B2 | Transistor, organic semiconductor device, and method for manufacture of the transistor or device | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2011-07-12 | — | — | US | disclosed |
| US-20090278116-A1 | TRANSISTOR, ORGANIC SEMICONDUCTOR DEVICE, AND METHOD FOR MANUFACTURE OF THE TRANSISTOR OR DEVICE | SUMITOMO CHEMICAL COMPANY LIMITED | 2009-11-12 | — | — | US | disclosed |
| US-20090267055-A1 | TRANSISTOR, METHOD FOR MANUFACTURING SAME, AND SEMICONDUCTOR DEVICE COMPRISING SUCH TRANSISTOR | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2009-10-29 | — | — | US | disclosed |