SCHEMBL8616729

SCHEMBL8616729

O=c1[nH]c2ccccc2c(=O)n1C(CCCSc1ccncc1)CSc1ccncc1

nearest known ligand 0.39

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.37
ALDH1A1 P00352 4/20 0.37
HPGD P15428 2/20 0.37
ADORA3 P0DMS8 1/20 0.36
ADORA2A P29274 1/20 0.36
ADORA2B P29275 1/20 0.36
ADORA1 P30542 1/20 0.36
CA12 O43570 1/20 0.36
RNASEH1 O60930 1/20 0.36
ERCC1 P07992 1/20 0.36
ERCC5 P28715 1/20 0.36
FEN1 P39748 1/20 0.36
CA9 Q16790 1/20 0.36
ERCC4 Q92889 1/20 0.36
KDM4E B2RXH2 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
GCK P35557 2/20 0.36
QPCT Q16769 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8619504 0.99 CYP1A2 (0.36) CYP1A2ALDH1A1HPGDADORA3ADORA2A
SCHEMBL8793473 0.78 ALDH1A1 (0.59) CYP1A2ALDH1A1HPGDKDM4ESMN1; SMN2
SCHEMBL8794286 0.77 ALDH1A1 (0.57) CYP1A2ALDH1A1HPGDKDM4ESMN1; SMN2
SCHEMBL6982369 0.66 KDM4E (0.60) CYP1A2ALDH1A1HPGDADORA3ADORA2A
SCHEMBL8614885 0.65 MAPK1 (0.47) ALDH1A1HPGDSMN1; SMN2
SCHEMBL2600725 0.64 ALDH1A1 (0.73) CYP1A2ALDH1A1HPGDADORA3ADORA2A
Hydrochloric Acid SCHEMBL8619108 0.64 MAPK1 (0.46) ALDH1A1HPGDSMN1; SMN2
SCHEMBL8614516 0.64 MAPK1 (0.43) ALDH1A1HPGDSMN1; SMN2
SCHEMBL22016197 0.64 ADORA3 (0.42) ALDH1A1HPGDADORA3ADORA2AADORA1
SCHEMBL24312482 0.62 ADORA3 (0.45) CYP1A2ALDH1A1HPGDADORA3ADORA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5767121-A ANTIINFLAMMATORY AND -ARTHRITIC AGENTS; ANTIPYRETICS; ANALGESICS; ADHESION PROTEIN EXPRESSION AND CYCLOXYGENASE AND 5-LIPOXYGENASE INHIBITORS; IMMUNOSUPPRESSANTS AND -MODULATORS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-06-16 US disclosed