SCHEMBL22016404

SCHEMBL22016404

Cc1ccccc1CN(C=S)Cc1ccccc1

nearest known ligand 0.42

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TAS2R14 Q9NYV8 1/20 0.42
MAPT P10636 1/20 0.41
KMT2A Q03164 4/20 0.41
ALDH1A1 P00352 3/20 0.41
MEN1 O00255 2/20 0.41
TSHR P16473 2/20 0.39
NR3C1 P04150 1/20 0.39
CYP19A1 P11511 1/20 0.38
AOC3 Q16853 1/20 0.37
CYP2C19 P33261 1/20 0.37
TRPM8 Q7Z2W7 1/20 0.36
MAPK1 P28482 1/20 0.36
TAAR1 Q96RJ0 1/20 0.36
GAA P10253 1/20 0.35
MGLL Q99685 1/20 0.35
CA12 O43570 1/20 0.35
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35
CA9 Q16790 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8335334 0.83 ALDH1A1 (0.48) ALDH1A1TSHRAOC3CYP2C19GAA
SCHEMBL21509737 0.80 MAPT (0.51) TAS2R14MAPTKMT2AALDH1A1MEN1
SCHEMBL9875884 0.80 MAPT (0.51) TAS2R14MAPTKMT2AALDH1A1MEN1
SCHEMBL11821323 0.76 TSHR (0.48) ALDH1A1TSHRAOC3CYP2C19MAPK1
SCHEMBL21509497 0.74 ALDH1A1 (0.56) TAS2R14KMT2AALDH1A1MEN1TSHR
SCHEMBL7048335 0.73 TAS2R14 (0.48) TAS2R14MAPTKMT2AALDH1A1MEN1
SCHEMBL189440 0.72 MAPT (0.60) MAPTKMT2AMEN1TSHRTAAR1
SCHEMBL10039140 0.71 CALM1 (0.52) TAS2R14MAPTKMT2AALDH1A1MEN1
SCHEMBL27359901 0.71 SLC6A2 (0.47) TAS2R14MAPTKMT2AALDH1A1MEN1
Hydrochloric Acid SCHEMBL1642885 0.71 ESR1 (0.44) TAS2R14MAPTKMT2AALDH1A1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3653611-A1 INHIBITORS OF METALLO-BETA-LACTAMASES CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2020-05-20 EP disclosed