Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | BRD9 | Q9H8M2 | 5/20 | 0.41 |
| ▸ | BRD4 | O60885 | 3/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.38 |
| ▸ | ITGA4 | P13612 | 3/20 | 0.38 |
| ▸ | ITGB7 | P26010 | 3/20 | 0.38 |
| ▸ | S100B | P04271 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4498149 | 0.78 | RAB9A (0.55) | ALDH1A1RAB9AL3MBTL1SMN1; SMN2BRD9 | |
| SCHEMBL466352 | 0.78 | ALDH1A1 (0.55) | ALDH1A1RAB9ASMN1; SMN2BRD9BRD4 | |
| SCHEMBL22031949 | 0.76 | KAT2B (0.39) | ALDH1A1RAB9AL3MBTL1SMN1; SMN2BRD9 | |
| SCHEMBL3055509 | 0.76 | ALDH1A1 (0.36) | ALDH1A1RAB9AL3MBTL1SMN1; SMN2BRD9 | |
| SCHEMBL22016782 | 0.76 | ITGA4 (0.38) | ALDH1A1RAB9AL3MBTL1SMN1; SMN2BRD9 | |
| SCHEMBL20956636 | 0.74 | CA12 (0.43) | ALDH1A1L3MBTL1KDM4EHTTITGA4 | |
| SCHEMBL509614 | 0.74 | CRHR1 (0.41) | ALDH1A1RAB9AL3MBTL1SMN1; SMN2ITGA4 | |
| SCHEMBL8280366 | 0.74 | ITGA4 (0.54) | ALDH1A1RAB9AL3MBTL1SMN1; SMN2ITGA4 | |
| SCHEMBL4296086 | 0.74 | BRD4 (0.38) | ALDH1A1L3MBTL1BRD9BRD4ATM | |
| SCHEMBL12497715 | 0.74 | BRD4 (0.46) | ALDH1A1SMN1; SMN2BRD9BRD4HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230041518-A1 | QUINOLINE DERIVATIVES | GILEAD SCIENCES, INC. | 2023-02-09 | — | — | US | disclosed |
| US-20220119383-A1 | QUINOLINE DERIVATIVES AS ALPHA4BETA7 INTEGRIN INHIBITORS | GILEAD SCIENCES, INC. | 2022-04-21 | — | — | US | disclosed |
| US-11116760-B2 | Quinoline derivatives | GILEAD SCIENCES, INC. (US) | 2021-09-14 | — | — | US | disclosed |
| US-20200155538-A1 | QUINOLINE DERIVATIVES | GILEAD SCIENCES, INC. | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230041518-A1 | QUINOLINE DERIVATIVES | CFTR, NQO1, IRF3 | ALDH1A1 476/4885RAB9A 271/4885L3MBTL1 4861/4885 |
| US-20200155538-A1 | QUINOLINE DERIVATIVES | CFTR, NQO1, IRF3 | ALDH1A1 476/4885RAB9A 271/4885L3MBTL1 4861/4885 |
| US-20220119383-A1 | QUINOLINE DERIVATIVES AS ALPHA4BETA7 INTEGRIN INHIBITORS | ITGB7, ITGB1, ITGA2B | ALDH1A1 838/4885RAB9A 247/4885L3MBTL1 4535/4885 |
| US-11116760-B2 | Quinoline derivatives | CFTR, NQO1, IRF3 | ALDH1A1 476/4885RAB9A 271/4885L3MBTL1 4861/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.