Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 3/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.45 |
| ▸ | BRD4 | O60885 | 8/20 | 0.43 |
| ▸ | BRD9 | Q9H8M2 | 8/20 | 0.43 |
| ▸ | BRD2 | P25440 | 4/20 | 0.43 |
| ▸ | BRD7 | Q9NPI1 | 4/20 | 0.43 |
| ▸ | EZH2 | Q15910 | 2/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.37 |
| ▸ | NQO2 | P16083 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22037773 | 0.77 | PDE3B (0.43) | PDE3BPDE3ABRD4BRD9BRD2 | |
| SCHEMBL22017507 | 0.77 | KDM4E (0.40) | BRD4BRD9EZH2ALDH1A1 | |
| SCHEMBL21955358 | 0.74 | PDE3B (0.42) | PDE3BPDE3ACYP19A1NQO2ALDH1A1 | |
| SCHEMBL24312086 | 0.71 | CYP19A1 (0.37) | PDE3BPDE3AEZH2CYP19A1NQO2 | |
| SCHEMBL22016469 | 0.71 | PDE3B (0.45) | PDE3BPDE3ACYP19A1NQO2ALDH1A1 | |
| SCHEMBL20051827 | 0.70 | ITGB1 (0.37) | ALDH1A1 | |
| SCHEMBL24312389 | 0.69 | LMNA (0.53) | PDE3BPDE3ABRD4BRD9BRD2 | |
| SCHEMBL22016884 | 0.68 | KMT2A (0.38) | ALDH1A1 | |
| SCHEMBL22016782 | 0.68 | ITGA4 (0.38) | PDE3BPDE3ABRD4BRD9ALDH1A1 | |
| SCHEMBL5141794 | 0.68 | ACHE (0.54) | PDE3BPDE3AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230041518-A1 | QUINOLINE DERIVATIVES | GILEAD SCIENCES, INC. | 2023-02-09 | — | — | US | disclosed |
| US-11174256-B2 | Imidazopyridine derivatives | GILEAD SCIENCES, INC. (US) | 2021-11-16 | — | — | US | disclosed |
| US-11116760-B2 | Quinoline derivatives | GILEAD SCIENCES, INC. (US) | 2021-09-14 | — | — | US | disclosed |
| US-20200165248-A1 | IMIDAZOPYRIDINE DERIVATIVES | GILEAD SCIENCES, INC. | 2020-05-28 | — | — | US | disclosed |
| US-20200155538-A1 | QUINOLINE DERIVATIVES | GILEAD SCIENCES, INC. | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230041518-A1 | QUINOLINE DERIVATIVES | CFTR, NQO1, IRF3 | PDE3B 87/4885PDE3A 266/4885BRD4 288/4885 |
| US-20200155538-A1 | QUINOLINE DERIVATIVES | CFTR, NQO1, IRF3 | PDE3B 87/4885PDE3A 266/4885BRD4 288/4885 |
| US-11174256-B2 | Imidazopyridine derivatives | TPMT, IRAK4, CFTR | PDE3B 42/4885PDE3A 62/4885BRD4 575/4885 |
| US-11116760-B2 | Quinoline derivatives | CFTR, NQO1, IRF3 | PDE3B 87/4885PDE3A 266/4885BRD4 288/4885 |
| US-20200165248-A1 | IMIDAZOPYRIDINE DERIVATIVES | TPMT, IRAK4, CFTR | PDE3B 42/4885PDE3A 62/4885BRD4 575/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.