Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | EZH2 | Q15910 | 5/20 | 0.36 |
| ▸ | EED | O75530 | 2/20 | 0.36 |
| ▸ | RBBP4 | Q09028 | 2/20 | 0.36 |
| ▸ | SUZ12 | Q15022 | 2/20 | 0.36 |
| ▸ | AEBP2 | Q6ZN18 | 2/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15647981 | 0.82 | KDM4E (0.39) | KDM4EL3MBTL1USP2LMNAALDH1A1 | |
| Hydrochloric Acid SCHEMBL16212688 | 0.80 | KDM4E (0.38) | KDM4EL3MBTL1USP2LMNAALDH1A1 | |
| SCHEMBL22016881 | 0.77 | PDE3B (0.45) | ALDH1A1EZH2BRD4BRD9 | |
| SCHEMBL18455423 | 0.77 | EZH2 (0.39) | KDM4EL3MBTL1USP2LMNAEZH2 | |
| SCHEMBL20051827 | 0.76 | ITGB1 (0.37) | KDM4EALDH1A1HPGDKDM5B | |
| SCHEMBL22016884 | 0.73 | KMT2A (0.38) | KDM4EL3MBTL1LMNAALDH1A1HPGD | |
| SCHEMBL4393645 | 0.73 | KDM4E (0.44) | KDM4EL3MBTL1USP2LMNAALDH1A1 | |
| Hydrochloric Acid SCHEMBL5487003 | 0.71 | KDM4E (0.43) | KDM4EL3MBTL1USP2LMNAALDH1A1 | |
| SCHEMBL11527852 | 0.70 | EZH2 (0.41) | KDM4EL3MBTL1ALDH1A1HPGDEZH2 | |
| SCHEMBL21977695 | 0.70 | KDM4E (0.42) | KDM4EL3MBTL1USP2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230041518-A1 | QUINOLINE DERIVATIVES | GILEAD SCIENCES, INC. | 2023-02-09 | — | — | US | disclosed |
| US-20220152014-A1 | COMPOUNDS FOR INHIBITION OF ALPHA 4 BETA 7 INTEGRIN | GILEAD SCIENCES, INC. (US) | 2022-05-19 | — | — | US | disclosed |
| US-11179383-B2 | Compounds for inhibition of α4β7 integrin | GILEAD SCIENCES, INC. (US) | 2021-11-23 | — | — | US | disclosed |
| US-11116760-B2 | Quinoline derivatives | GILEAD SCIENCES, INC. (US) | 2021-09-14 | — | — | US | disclosed |
| US-20200163953-A1 | Compounds for Inhibition of Alpha 4 Beta 7 Integrin | GILEAD SCIENCES, INC. | 2020-05-28 | — | — | US | disclosed |
| US-20200155538-A1 | QUINOLINE DERIVATIVES | GILEAD SCIENCES, INC. | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200163953-A1 | Compounds for Inhibition of Alpha 4 Beta 7 Integrin | ITGB7, ITGB4, ITGA4 | KDM4E 1442/4885L3MBTL1 4194/4885USP2 4585/4885 |
| US-11179383-B2 | Compounds for inhibition of α4β7 integrin | ITGB7, ITGB4, ITGA4 | KDM4E 1209/4885L3MBTL1 4321/4885USP2 4552/4885 |
| US-20230041518-A1 | QUINOLINE DERIVATIVES | CFTR, NQO1, IRF3 | KDM4E 2522/4885L3MBTL1 4861/4885USP2 2720/4885 |
| US-20200155538-A1 | QUINOLINE DERIVATIVES | CFTR, NQO1, IRF3 | KDM4E 2522/4885L3MBTL1 4861/4885USP2 2720/4885 |
| US-20220152014-A1 | COMPOUNDS FOR INHIBITION OF ALPHA 4 BETA 7 INTEGRIN | ITGB7, ITGB4, ITGA4 | KDM4E 1442/4885L3MBTL1 4194/4885USP2 4585/4885 |
| US-11116760-B2 | Quinoline derivatives | CFTR, NQO1, IRF3 | KDM4E 2522/4885L3MBTL1 4861/4885USP2 2720/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.