Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.64 |
| ▸ | ABL1 | P00519 | 6/20 | 0.49 |
| ▸ | BCR | P11274 | 3/20 | 0.49 |
| ▸ | HCK | P08631 | 1/20 | 0.48 |
| ▸ | GCK | P35557 | 1/20 | 0.48 |
| ▸ | NR2C2 | P49116 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 7/20 | 0.47 |
| ▸ | EGFR | P00533 | 5/20 | 0.47 |
| ▸ | LYN | P07948 | 3/20 | 0.46 |
| ▸ | CSK | P41240 | 2/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.46 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | ARAF | P10398 | 1/20 | 0.46 |
| ▸ | NQO2 | P16083 | 1/20 | 0.46 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.46 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22018092 | 0.88 | BRAF (0.60) | ABL1BRAFEGFR | |
| SCHEMBL22018093 | 0.85 | BRAF (0.59) | ABL1BRAFEGFR | |
| SCHEMBL22017753 | 0.85 | TMPRSS2 (0.87) | TMPRSS2ABL1BCRBRAFEGFR | |
| SCHEMBL22017408 | 0.80 | TMPRSS2 (0.79) | TMPRSS2ABL1BCRBRAFEGFR | |
| SCHEMBL22018087 | 0.78 | TMPRSS2 (0.54) | TMPRSS2HCKNR2C2BRAFEGFR | |
| SCHEMBL22017772 | 0.77 | BRAF (0.64) | ABL1BRAFEGFRMAP3K7MAP4K2 | |
| SCHEMBL22017247 | 0.76 | BRAF (0.62) | ABL1BRAFEGFR | |
| SCHEMBL22017241 | 0.75 | KIT (0.62) | ABL1BRAFEGFRRET | |
| SCHEMBL22017577 | 0.74 | CREBBP (0.49) | HCKGCKNR2C2BRAFARAF | |
| SCHEMBL22018091 | 0.72 | KIT (0.61) | ABL1BRAFEGFRRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020098710-A1 | SUBSTITUTED BIS-ARYL AMIDE COMPOUND AND PREPARATION METHOD AND APPLICATION THEREFOR | 中国医学科学院医药生物技术研究所 | 2020-05-22 | — | — | WO | disclosed |