Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.54 |
| ▸ | HCK | P08631 | 1/20 | 0.47 |
| ▸ | NR2C2 | P49116 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 5/20 | 0.46 |
| ▸ | EGFR | P00533 | 4/20 | 0.46 |
| ▸ | KIT | P10721 | 3/20 | 0.46 |
| ▸ | MAP3K7 | O43318 | 4/20 | 0.45 |
| ▸ | MAP4K2 | Q12851 | 4/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.43 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.43 |
| ▸ | FES | P07332 | 1/20 | 0.43 |
| ▸ | FER | P16591 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22017241 | 0.86 | KIT (0.62) | BRAFEGFRKITRET | |
| SCHEMBL22018091 | 0.84 | KIT (0.61) | BRAFEGFRKITRET | |
| SCHEMBL22017771 | 0.79 | MAPT (0.47) | HCKNR2C2BRAFEGFRKIT | |
| SCHEMBL22017588 | 0.78 | TMPRSS2 (0.64) | TMPRSS2HCKNR2C2BRAFEGFR | |
| SCHEMBL22017753 | 0.78 | TMPRSS2 (0.87) | TMPRSS2BRAFEGFRKITRET | |
| SCHEMBL22018092 | 0.74 | BRAF (0.60) | BRAFEGFRKIT | |
| SCHEMBL22017242 | 0.74 | TMPRSS2 (0.65) | TMPRSS2BRAFKITHTTRET | |
| SCHEMBL22017401 | 0.74 | TMPRSS2 (0.68) | TMPRSS2BRAFEGFRKITRET | |
| SCHEMBL22017245 | 0.73 | KIT (0.65) | BRAFEGFRKITRET | |
| SCHEMBL31053460 | 0.72 | RAB9A (0.53) | TMPRSS2BRAFKITLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020098710-A1 | SUBSTITUTED BIS-ARYL AMIDE COMPOUND AND PREPARATION METHOD AND APPLICATION THEREFOR | 中国医学科学院医药生物技术研究所 | 2020-05-22 | — | — | WO | disclosed |