SCHEMBL22018208

SCHEMBL22018208

CCC(CC)n1c(=O)c2ccc3c4ccccc4sc4c(C#Cc5ccc(N)s5)cc(c1=O)c2c43

nearest known ligand 0.32

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.32
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
HTT P42858 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
ALDH1A1 P00352 2/20 0.31
TP53 P04637 2/20 0.31
KDM4E B2RXH2 1/20 0.30
LMNA P02545 1/20 0.30
TSHR P16473 1/20 0.30
MAPK1 P28482 1/20 0.30
HSD17B10 Q99714 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22018211 0.87 MEN1 (0.37) MAPTMEN1KMT2AHTTNPSR1
SCHEMBL22018386 0.85 HCRTR1 (0.36) MAPTMEN1KMT2AHTTNPSR1
SCHEMBL22018210 0.85 MEN1 (0.31) MAPTMEN1KMT2AHTTNPSR1
SCHEMBL22018385 0.83 MAPT (0.31) MAPTMEN1KMT2AHTTNPSR1
SCHEMBL22019247 0.83 MAPT (0.33) MAPTALDH1A1TP53KDM4EMAPK1
SCHEMBL22018214 0.82 NPC1 (0.30)
SCHEMBL22018227 0.81 TP53 (0.30) MAPTTP53
SCHEMBL22018213 0.78 KMT2A (0.36) MAPTMEN1KMT2AHTTNPSR1
SCHEMBL22019251 0.75
SCHEMBL22018615 0.74 ALDH1A1 (0.41) MAPTMEN1KMT2AHTTNPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020099793-A1 NOVEL BENZOTHIOXANTHENE P-CONJUGATED MOLECULES FOR ENERGY STORAGE UNIVERSITE D'ANGERS (FR) 2020-05-22 WO disclosed