SCHEMBL22018386

SCHEMBL22018386

CCC(CC)n1c(=O)c2ccc3c4ccccc4sc4c(C#Cc5cccc(N)c5)cc(c1=O)c2c43

nearest known ligand 0.36

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HCRTR1 O43613 1/20 0.36
RAB9A P51151 3/20 0.35
ADRB2 P07550 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
NPC1 O15118 1/20 0.32
ALDH1A1 P00352 2/20 0.32
MAPT P10636 3/20 0.32
HPGD P15428 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
TP53 P04637 1/20 0.32
HTT P42858 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
PIK3CA P42336 1/20 0.30
MTOR P42345 1/20 0.30
PDK1 Q15118 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22018211 0.91 MEN1 (0.37) RAB9AL3MBTL1MEN1KMT2ANPC1
SCHEMBL22018208 0.85 MAPT (0.32) MEN1KMT2AALDH1A1MAPTTP53
SCHEMBL22018372 0.83 MAPT (0.33) HCRTR1RAB9AADRB2L3MBTL1ALDH1A1
SCHEMBL22018385 0.83 MAPT (0.31) RAB9AMEN1KMT2AALDH1A1MAPT
SCHEMBL22018210 0.83 MEN1 (0.31) MEN1KMT2AALDH1A1MAPTHTT
SCHEMBL22018387 0.80 RAB9A (0.46) HCRTR1RAB9AADRB2L3MBTL1MEN1
SCHEMBL22018213 0.77 KMT2A (0.36) RAB9AL3MBTL1MEN1KMT2AALDH1A1
SCHEMBL22018615 0.72 ALDH1A1 (0.41) RAB9AL3MBTL1MEN1KMT2ANPC1
SCHEMBL22018384 0.71 MEN1 (0.44) RAB9AADRB2L3MBTL1MEN1KMT2A
SCHEMBL22018214 0.68 NPC1 (0.30) RAB9ANPC1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020099793-A1 NOVEL BENZOTHIOXANTHENE P-CONJUGATED MOLECULES FOR ENERGY STORAGE UNIVERSITE D'ANGERS (FR) 2020-05-22 WO disclosed