Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1I | Q9P0X4 | 9/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.37 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22019049 | 0.89 | CACNA1I (0.47) | CACNA1IKCNH2NPC1RAB9AENPP2 | |
| SCHEMBL4273159 | 0.86 | CACNA1I (0.49) | CACNA1IKCNH2NPC1RAB9AENPP2 | |
| SCHEMBL22018853 | 0.85 | RAB9A (0.50) | CACNA1IKCNH2NPC1RAB9AENPP2 | |
| SCHEMBL19112992 | 0.81 | CACNA1I (0.47) | CACNA1IKCNH2NPC1RAB9AENPP2 | |
| SCHEMBL19112805 | 0.81 | CACNA1I (0.48) | CACNA1IKCNH2NPC1RAB9AENPP2 | |
| SCHEMBL4275836 | 0.80 | CACNA1I (0.46) | CACNA1IKCNH2NPC1RAB9AENPP2 | |
| SCHEMBL4278734 | 0.80 | CACNA1I (0.43) | CACNA1IKCNH2NPC1RAB9AENPP2 | |
| SCHEMBL4270993 | 0.79 | CACNA1I (0.45) | CACNA1IKCNH2NPC1RAB9ACA12 | |
| SCHEMBL4272368 | 0.78 | CACNA1I (0.44) | CACNA1IKCNH2NPC1RAB9AENPP2 | |
| SCHEMBL4269196 | 0.78 | CACNA1I (0.46) | CACNA1IKCNH2NPC1RAB9ACA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189839-B1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | PRAXIS PREC MEDICINES INC (US) | 2020-05-20 | — | — | EP | disclosed |