SCHEMBL22019146

SCHEMBL22019146

CS(=O)(=O)c1cccc(C(=O)c2cnc(N3CCC(c4cccnc4)C3)s2)c1

nearest known ligand 0.42

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
VNN1 O95497 4/20 0.42
MLYCD O95822 4/20 0.40
CYP3A4 P08684 1/20 0.38
CYP2C9 P11712 1/20 0.38
NAMPT P43490 1/20 0.38
PDE10A Q9Y233 1/20 0.37
AOC3 Q16853 1/20 0.36
SPR P35270 1/20 0.36
DRD2 P14416 2/20 0.36
DRD3 P35462 1/20 0.36
BRAF P15056 1/20 0.36
SLC9A1 P19634 1/20 0.36
SIGMAR1 Q99720 1/20 0.36
HSD11B1 P28845 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21962694 1.00 VNN1 (0.42) VNN1MLYCDCYP3A4CYP2C9NAMPT
SCHEMBL21962524 0.91 MLYCD (0.43) MLYCDDRD2
SCHEMBL22019318 0.91 MLYCD (0.43) MLYCDDRD2
SCHEMBL22019140 0.86 CCR2 (0.47) VNN1MLYCDCYP2C9SLC9A1
SCHEMBL22019316 0.86 DRD2 (0.43) MLYCDDRD2DRD3
SCHEMBL21962773 0.86 CCR2 (0.47) VNN1MLYCDCYP2C9SLC9A1
SCHEMBL21962693 0.86 DRD2 (0.43) MLYCDDRD2DRD3
SCHEMBL21962393 0.84 MLYCD (0.44) VNN1MLYCDBRAF
SCHEMBL22019315 0.84 MLYCD (0.44) VNN1MLYCDBRAF
SCHEMBL22020520 0.84 RAF1 (0.42) VNN1MLYCDBRAF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020102575-A1 HETEROCYCLIC AMINOTHIAZOLES AND USES THEREOF INCEPTION IBD, INC. (US) 2020-05-22 WO disclosed