Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR3 | P49682 | 3/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.45 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | WNT3 | P56703 | 1/20 | 0.42 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RHOC | P08134 | 3/20 | 0.41 |
| ▸ | RHOA | P61586 | 3/20 | 0.41 |
| ▸ | ACP1 | P24666 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12004594 | 0.91 | CXCR3 (0.44) | CXCR3EPHX2HCRTR1HCRTR2NAMPT | |
| SCHEMBL12004663 | 0.88 | RHOC (0.44) | CXCR3HCRTR1HCRTR2NAMPTWNT3 | |
| SCHEMBL6863162 | 0.87 | CXCR3 (0.42) | CXCR3EPHX2HCRTR1HCRTR2NAMPT | |
| SCHEMBL1444264 | 0.84 | EPHX2 (0.49) | CXCR3EPHX2NAMPTKCNH2RHOC | |
| SCHEMBL4272965 | 0.83 | HSD17B10 (0.52) | CXCR3EPHX2HCRTR1HCRTR2WNT3 | |
| SCHEMBL4272968 | 0.83 | HSD17B10 (0.52) | CXCR3EPHX2HCRTR1HCRTR2WNT3 | |
| SCHEMBL4276665 | 0.83 | HSD17B10 (0.52) | CXCR3EPHX2HCRTR1HCRTR2WNT3 | |
| SCHEMBL4274713 | 0.81 | HSD17B10 (0.48) | CXCR3EPHX2HCRTR1HCRTR2NAMPT | |
| SCHEMBL1445327 | 0.81 | LMNA (0.52) | CXCR3EPHX2NAMPTGAALMNA | |
| SCHEMBL12005602 | 0.79 | RHOA (0.45) | CXCR3EPHX2RHOCRHOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189839-B1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | PRAXIS PREC MEDICINES INC (US) | 2020-05-20 | — | — | EP | disclosed |