Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
| ▸ | BPTF | Q12830 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22020056 | 0.84 | KMT2A (0.36) | KMT2AMEN1MAPTTDP1GAA | |
| SCHEMBL21963168 | 0.84 | ACHE (0.43) | KMT2AMEN1MAPTTDP1KDM4E | |
| SCHEMBL22019991 | 0.80 | KMT2A (0.33) | KMT2AMEN1MAPTTDP1GAA | |
| SCHEMBL22019989 | 0.79 | KMT2A (0.34) | KMT2AMEN1MAPTTDP1GAA | |
| SCHEMBL22020719 | 0.78 | SMN1; SMN2 (0.41) | KMT2AMEN1MAPTTDP1GAA | |
| SCHEMBL21963362 | 0.77 | ACHE (0.46) | KMT2AMEN1KDM4EMAPK1ALDH1A1 | |
| SCHEMBL24977994 | 0.72 | SMN1; SMN2 (0.41) | KMT2AMEN1MAPTTDP1GAA | |
| SCHEMBL22019776 | 0.69 | KDM4E (0.33) | KMT2AMEN1MAPTGAACYP1A2 | |
| SCHEMBL22020517 | 0.68 | ACHE (0.48) | KMT2AMEN1MAPTGAACYP1A2 | |
| SCHEMBL22019990 | 0.67 | NOS3 (0.46) | KMT2AMEN1MAPTTDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020102096-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |