Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOBEC3A | P31941 | 1/20 | 0.47 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 4/20 | 0.33 |
| ▸ | METAP1 | P53582 | 1/20 | 0.33 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.32 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.32 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.32 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.32 |
| ▸ | SRC | P12931 | 2/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30708692 | 0.80 | APOBEC3A (0.61) | APOBEC3AAPOBEC3GKDRRAB9ADYRK1A | |
| SCHEMBL3788143 | 0.76 | PDPK1 (0.47) | PDPK1KDRRAB9AHSP90AA1CYP2A6 | |
| SCHEMBL2748696 | 0.76 | APOBEC3A (0.46) | APOBEC3AAPOBEC3GDYRK1ACYP1A2 | |
| SCHEMBL30118007 | 0.75 | APOBEC3A (0.56) | APOBEC3AAPOBEC3GKDRRAB9ADYRK1A | |
| SCHEMBL16265168 | 0.75 | DYRK1A (0.54) | PDPK1KDRRAB9AHSP90AA1DYRK1A | |
| SCHEMBL1665644 | 0.74 | APOBEC3A (0.54) | APOBEC3AAPOBEC3GKDRRAB9ADYRK1A | |
| SCHEMBL29846190 | 0.74 | PDPK1 (0.41) | PDPK1KDRRAB9AHSP90AA1SMPD3 | |
| SCHEMBL30798766 | 0.71 | APOBEC3A (0.51) | APOBEC3AAPOBEC3GKDRRAB9AHSP90AA1 | |
| SCHEMBL1015835 | 0.71 | DYRK1A (0.62) | APOBEC3AAPOBEC3GKDRRAB9ADYRK1A | |
| Hydrochloric Acid SCHEMBL25276515 | 0.70 | DYRK1A (0.60) | APOBEC3AAPOBEC3GKDRRAB9ADYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8563718-B2 | Thiazolyl-pyrazolopyrimidine compounds as synthetic intermediates and related synthetic processes | ELI LILLY AND COMPANY (US) | 2013-10-22 | — | — | US | disclosed |
| EP-2350079-B1 | THIAZOLYL-PYRAZOLOPYRIMIDINE COMPOUNDS AS SYNTHETIC INTERMEDIATES AND RELATED SYNTHETIC PROCESSES | LILLY CO ELI (US) | 2012-11-14 | — | — | EP | disclosed |
| US-20110166345-A1 | THIAZOLYL-PYRAZOLOPYRIMIDINE COMPOUNDS AS SYNTHETIC INTERMEDIATES AND RELATED SYNTHETIC PROCESSES | ELI LILLY AND COMPANY (US) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166345-A1 | THIAZOLYL-PYRAZOLOPYRIMIDINE COMPOUNDS AS SYNTHETIC INTERMEDIATES AND RELATED SYNTHETIC PROCESSES | FDPS, DHFR, TPMT | APOBEC3A 3613/4885APOBEC3G 3865/4885PDPK1 813/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.