Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 6/20 | 0.38 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 2/20 | 0.37 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | METAP1 | P53582 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20186115 | 0.75 | DYRK1A (0.54) | DYRK1ARAB9ASCN5ATGFBR1CYP1A2 | |
| SCHEMBL4902877 | 0.73 | RAB9A (0.61) | RAB9AHSP90AA1PDPK1SYKCYP1A1 | |
| SCHEMBL3162678 | 0.70 | DYRK1A (0.65) | DYRK1ARAB9AHSP90AA1SCN5ATGFBR1 | |
| SCHEMBL3781186 | 0.70 | RAB9A (0.51) | DYRK1ARAB9APDPK1 | |
| SCHEMBL3498318 | 0.69 | DYRK1A (0.63) | DYRK1ARAB9ASCN5ATGFBR1CYP1A2 | |
| SCHEMBL1440869 | 0.69 | DYRK1A (0.49) | DYRK1ASCN5ATGFBR1PIK3CD | |
| SCHEMBL10376702 | 0.69 | HSP90AA1 (0.47) | RAB9AHSP90AA1PDPK1SYKCYP1A1 | |
| SCHEMBL30603240 | 0.69 | DYRK1A (0.50) | DYRK1ARAB9ASCN5ATGFBR1PIK3CD | |
| SCHEMBL20202141 | 0.69 | DYRK1A (0.54) | DYRK1ASCN5ATGFBR1PIK3CD | |
| SCHEMBL26516074 | 0.69 | TGFBR1 (0.50) | DYRK1ARAB9ASCN5ATGFBR1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8563718-B2 | Thiazolyl-pyrazolopyrimidine compounds as synthetic intermediates and related synthetic processes | ELI LILLY AND COMPANY (US) | 2013-10-22 | — | — | US | disclosed |
| EP-2350079-B1 | THIAZOLYL-PYRAZOLOPYRIMIDINE COMPOUNDS AS SYNTHETIC INTERMEDIATES AND RELATED SYNTHETIC PROCESSES | LILLY CO ELI (US) | 2012-11-14 | — | — | EP | disclosed |
| US-20110166345-A1 | THIAZOLYL-PYRAZOLOPYRIMIDINE COMPOUNDS AS SYNTHETIC INTERMEDIATES AND RELATED SYNTHETIC PROCESSES | ELI LILLY AND COMPANY (US) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166345-A1 | THIAZOLYL-PYRAZOLOPYRIMIDINE COMPOUNDS AS SYNTHETIC INTERMEDIATES AND RELATED SYNTHETIC PROCESSES | FDPS, DHFR, TPMT | DYRK1A 2796/4885RAB9A 2908/4885HSP90AA1 4125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.