SCHEMBL2202945

SCHEMBL2202945

C=CCc1cnc(N)nc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DHFR P00374 2/20 0.37
ALDH1A1 P00352 3/20 0.34
XDH P47989 1/20 0.34
TP53 P04637 1/20 0.34
CYP3A4 P08684 1/20 0.34
ALOX15 P16050 1/20 0.34
TSHR P16473 1/20 0.34
ALOX12 P18054 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
PPARG P37231 2/20 0.33
PPARD Q03181 2/20 0.33
KDM4E B2RXH2 1/20 0.33
MEN1 O00255 1/20 0.33
ALDH2 P05091 1/20 0.33
GAA P10253 1/20 0.33
MAPT P10636 1/20 0.33
GABRA1 P14867 1/20 0.33
AKR1B1 P15121 1/20 0.33
HPGD P15428 1/20 0.33
CNR1 P21554 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1647573 0.78 HDAC1 (0.35) DHFRMAPTGABRA1GABRB2HSP90AA1
SCHEMBL6683119 0.76 ALDH1A1 (0.34) ALDH1A1XDHTP53CYP3A4ALOX15
SCHEMBL10822233 0.76 XDH (0.43) DHFRALDH1A1XDHTP53CYP3A4
SCHEMBL9617311 0.76 ALDH1A1 (0.39) ALDH1A1XDHTP53CYP3A4ALOX15
SCHEMBL6681689 0.76 ALDH1A1 (0.38) ALDH1A1XDHTP53CYP3A4ALOX15
SCHEMBL8585824 0.76 GABRA1 (0.48) ALDH1A1XDHTP53CYP3A4ALOX15
SCHEMBL5433410 0.72
SCHEMBL887237 0.70
SCHEMBL10822219 0.70 XDH (0.38) ALDH1A1XDHCYP3A4ALOX15TSHR
SCHEMBL9638630 0.70 ALDH1A1 (0.42) ALDH1A1XDHTP53CYP3A4ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108367020-A Method for inhibiting tumors by miR-200 family inhibition 国立大学法人千叶大学 2018-08-03 CN disclosed
CN-102264898-B Method for inhibiting function of micro-RNA NAT UNIV CORP UNIV TOKYO 2013-10-16 CN disclosed
CN-102264898-A Method for inhibiting function of micro-RNA 2011-11-30 CN disclosed
US-20110166200-A1 METHODS OF USING MIR210 AS A BIOMARKER FOR HYPOXIA AND AS A THERAPEUTIC AGENT FOR TREATING CANCER ZHANG ZHAN 2011-07-07 US disclosed
WO-2009131887-A2 METHODS OF USING MIR210 AS A BIOMARKER FOR HYPOXIA AND AS A THERAPEUTIC AGENT FOR TREATING CANCER MERCK & CO., INC. (US) 2009-10-29 WO disclosed
US-7297532-B2 Surface based translation system THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2007-11-20 US disclosed
WO-2003064608-A9 SURFACE BASED TRANSLATION SYSTEM UNIV LELAND STANFORD JUNIOR (US) 2004-05-27 WO disclosed
US-20040023256-A1 Translation profiling BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, THE 2004-02-05 US disclosed
US-20030219783-A1 Surface based translation system NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2003-11-27 US disclosed
WO-2003064604-A2 TRANSLATION PROFILING THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2003-08-07 WO disclosed
WO-2003064608-A2 SURFACE BASED TRANSLATION SYSTEM THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2003-08-07 WO disclosed
US-3974159-A Manufacture of derivatives of malondialdehyde BASF AKTIENGESELLSCHAFT (DT) 1976-08-10 US disclosed