Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | SI | P14410 | 1/20 | 0.33 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10988574 | 1.00 | CTSL (0.37) | CTSLCTSBCTSSCTSKSMN1; SMN2 | |
| SCHEMBL12213979 | 0.84 | SMN1; SMN2 (0.40) | SMN1; SMN2ALDH1A1HPGDMAPK1CHRNB2 | |
| SCHEMBL10985225 | 0.84 | CTSL (0.40) | CTSLCTSBCTSSCTSKSMN1; SMN2 | |
| SCHEMBL12629160 | 0.83 | FAAH (0.37) | CTSLCTSBCTSSCTSKLMNA | |
| SCHEMBL10980085 | 0.83 | FAAH (0.37) | CTSLCTSBCTSSCTSKLMNA | |
| SCHEMBL21403713 | 0.81 | ALDH1A1 (0.35) | CTSLCTSBCTSSCTSKLMNA | |
| SCHEMBL3154599 | 0.80 | FAAH (0.37) | CTSLCTSBCTSSCTSKMEN1 | |
| SCHEMBL288906 | 0.80 | FAAH (0.37) | CTSLCTSBCTSSCTSKMEN1 | |
| SCHEMBL15663456 | 0.80 | FAAH (0.37) | CTSLCTSBCTSSCTSKMEN1 | |
| SCHEMBL6625590 | 0.79 | CYP2C9 (0.38) | MEN1KMT2AFAAHTSHRACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200165211-A1 | Compounds, Compositions, and Methods for Treating T-Cell Acute Lymphoblastic Leukemia | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2020-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200165211-A1 | Compounds, Compositions, and Methods for Treating T-Cell Acute Lymphoblastic Leukemia | BCL9, BCL3, MCL1 | CTSL 756/4885CTSB 1047/4885CTSS 1106/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.