Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 2/20 | 0.48 |
| ▸ | AR | P10275 | 2/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 7/20 | 0.40 |
| ▸ | GABRP | O00591 | 1/20 | 0.40 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.40 |
| ▸ | GABRE | P78334 | 1/20 | 0.40 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.40 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.40 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.40 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.40 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21620288 | 0.73 | CYP1A2 (0.46) | PDK2HSD11B1CYP1A2CYP1A1PLA2G7 | |
| SCHEMBL20108429 | 0.70 | TSHR (0.38) | PDK2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL18272233 | 0.70 | SMN1; SMN2 (0.40) | ARRAPGEF4CYP1A2MEN1CYP3A4 | |
| SCHEMBL5541462 | 0.69 | HSD11B1 (0.55) | ARHSD11B1TRPA1CYP3A4CYP2D6 | |
| SCHEMBL10493689 | 0.69 | RAPGEF4 (0.42) | PDK2HSD11B1RAPGEF4CYP3A4 | |
| SCHEMBL12881255 | 0.69 | RAPGEF4 (0.42) | PDK2HSD11B1RAPGEF4CYP2C19 | |
| SCHEMBL25350488 | 0.69 | HSD11B1 (0.43) | ARHSD11B1GABRPGABRDGABRA1 | |
| SCHEMBL4265966 | 0.68 | PDK2 (0.44) | PDK2CYP1A2TRPA1TSHR | |
| SCHEMBL17407435 | 0.68 | PDK2 (0.47) | PDK2HSD11B1CYP1A2CYP1A1MEN1 | |
| SCHEMBL14744241 | 0.68 | PLA2G7 (0.55) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200163937-A1 | PYRAZOLE-AMIDE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC (JP) | 2020-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200163937-A1 | PYRAZOLE-AMIDE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | NAT1, CYP2C19, CYP3A5 | PDK2 92/4885AR 2663/4885HSD11B1 1037/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.