Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TLR2 | O60603 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20766755 | 0.81 | ALDH1A1 (0.37) | LMNAKMT2AGAAALDH1A1HPGD | |
| SCHEMBL31035638 | 0.79 | HTR6 (0.36) | LMNAGAAALDH1A1SRCTLR2 | |
| SCHEMBL29722800 | 0.78 | ALDH1A1 (0.48) | LMNAKMT2AGAAALDH1A1HPGD | |
| SCHEMBL1201100 | 0.78 | ALDH1A1 (0.48) | LMNAKMT2AGAAALDH1A1HPGD | |
| SCHEMBL7149802 | 0.75 | CA12 (0.32) | LMNAKMT2AGAA | |
| SCHEMBL7698624 | 0.75 | TSHR (0.44) | LMNAGAAALDH1A1HPGDTDP1 | |
| SCHEMBL3548569 | 0.74 | ALDH1A1 (0.43) | LMNAKMT2AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL875044 | 0.74 | BACE1 (0.39) | LMNAKMT2AGAAALDH1A1HPGD | |
| SCHEMBL4522331 | 0.74 | ALDH1A1 (0.40) | KMT2AALDH1A1HTTSMN1; SMN2CYP2C9 | |
| SCHEMBL7220710 | 0.74 | PRKDC (0.33) | LMNAKMT2AGAAALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020117832-A1 | SMALL MOLECULE INHIBITORS OF THE BFRB:BFD INTERACTION | UNIVERSITY OF KANSAS (US) | 2020-06-11 | — | — | WO | disclosed |