Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.36 |
| ▸ | STS | P08842 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8456921 | 0.92 | ALDH1A1 (0.37) | ALDH1A1CYP2A6SMN1; SMN2LMNAKDM4E | |
| SCHEMBL25414124 | 0.84 | ALDH1A1 (0.41) | ALDH1A1LMNAKMT2ARAB9AMEN1 | |
| SCHEMBL4521425 | 0.83 | MAOA (0.47) | ALDH1A1CYP2A6LMNAKMT2AMAPT | |
| SCHEMBL704145 | 0.82 | CA4 (0.37) | ALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL6704403 | 0.82 | PREP (0.32) | ALDH1A1PPARGMAPT | |
| SCHEMBL6058610 | 0.81 | ALDH1A1 (0.31) | ALDH1A1MAPT | |
| SCHEMBL3686163 | 0.80 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2LMNAKDM4EPPARG | |
| SCHEMBL27600931 | 0.80 | CA4 (0.46) | ALDH1A1LMNAKDM4EKMT2ARAB9A | |
| SCHEMBL6058734 | 0.78 | ALDH1A1 (0.37) | ALDH1A1LMNAKDM4EKMT2AMEN1 | |
| SCHEMBL20594005 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090233930-A9 | Novel 2-Amino-Imidazole-4-One Compounds and Their Use in the Manufacture of a Medicament to Be Used in the Treatment of Cognitive Impairment, Alzheimer's Disease, Neurodegeneration and Dementia | ASTRAZENECA AB (SE) | 2009-09-17 | — | — | US | claimed |
| US-20080293718-A1 | Novel 2-Amino-Imidazole-4-One Compounds and Their Use in the Manufacture of a Medicament to Be Used in the Treatment of Cognitive Impairment, Alzheimer's Disease, Neurodegeneration and Dementia | ASTRAZENECA AB (SE) | 2008-11-27 | — | — | US | claimed |
| EP-1979324-A2 | NOVEL 2-AMINO-IMIDAZOLE-4-ONE COMPOUNDS AND THEIR USE IN THE MANUFACTURE OF A MEDICAMENT TO BE USED IN THE TREATMENT OF COGNITIVE IMPAIRMENT, ALZHEIMER'S DISEASE, NEURODEGENERATION AND DEMENTIA | Astra Zeneca AB (SE) | 2008-10-15 | — | — | EP | claimed |
| WO-2007058602-A2 | NOVEL 2-AMINO-IMIDAZOLE-4-ONE COMPOUNDS AND THEIR USE IN THE MANUFACTURE OF A MEDICAMENT TO BE USED IN THE TREATMENT OF COGNITIVE IMPAIRMENT, ALZHEIMER’S DISEASE, NEURODEGENERATION AND DEMENTIA. | ASTRAZENECA AB (SE) | 2007-05-24 | — | — | WO | claimed |
| US-10865218-B2 | Fluoride fluorescence probe | THE PROCTER & GAMBLE COMPANY (US) | 2020-12-15 | — | — | US | disclosed |
| EP-3642186-A1 | FLUORIDE FLUORESCENCE PROBE | The Procter and Gamble Company (US) | 2020-04-29 | — | — | EP | disclosed |
| CN-110785410-A | Fluorine ion fluorescent probe | 宝洁公司 | 2020-02-11 | — | — | CN | disclosed |
| US-20180370996-A1 | FLUORIDE FLUORESCENCE PROBE | FUDAN UNIVERSITY (CN) | 2018-12-27 | — | — | US | disclosed |
| WO-2018232675-A1 | FLUORIDE FLUORESCENCE PROBE | THE PROCTER & GAMBLE COMPANY (US) | 2018-12-27 | — | — | WO | disclosed |
| CN-105153217-A | Efficient preparation method of colorimetric probe | JINJIANG SHANGJING FUBEN ENVRIONMENTAL PROT TECHNOLOGY CO LTD | 2015-12-16 | — | — | CN | disclosed |
| WO-2011019995-A2 | SYNTHESIS AND IDENTIFICATION OF NOVEL RSK-SPECIFIC INHIBITORS | HECHT SIDNEY M (US) | 2011-02-17 | — | — | WO | disclosed |
| WO-2010097350-A1 | A PROCESS FOR THE PREPARATION OF AN ALDEHYDE BETA-LACTAM COMPOUND | ADAMED SP. Z O.O. (PL) | 2010-09-02 | — | — | WO | disclosed |
| US-20050240062-A1 | Structural modification of resveratrol: Sodium resverastatin phosphate | NATIONAL INSTITUTES OF HEALTH | 2005-10-27 | — | — | US | disclosed |
| WO-2003086414-A1 | STRUCTURAL MODIFICATION OF RESVERATROL: SODIUM RESVERASTATIN PHOSPHATE | ARIZONA BOARD OF REGENTS (US) | 2003-10-23 | — | — | WO | disclosed |
| US-6063789-A | Aminoisoquinolines and aminotheinopyridine derivatives and their use as anti-inflammatory agents | ASTRA PHARMACEUTICALS, LTD. (GB) | 2000-05-16 | — | — | US | disclosed |
| EP-0892784-A1 | AMINOISOQUINOLINES AND AMINOTHIENOPYRIDINE DERIVATIVES AND THEIR USE AS ANTI-INFLAMMATORY AGENTS | Astra Pharmaceuticals Limited (GB) | 1999-01-27 | — | — | EP | disclosed |
| WO-1997038977-A1 | AMINOISOQUINOLINES AND AMINOTHIENOPYRIDINE DERIVATIVES AND THEIR USE AS ANTI-INFLAMMATORY AGENTS | ASTRA PHARMACEUTICALS LTD. (GB) | 1997-10-23 | — | — | WO | disclosed |
| US-5453443-A | Antiallergens, antiinflammatory | MERCK FROSST CANADA, INC. (CA) | 1995-09-26 | — | — | US | disclosed |
| US-5232916-A | Inhibitors of leukotriene synthesis | MERCK FROSST CANADA, INC. (CA) | 1993-08-03 | — | — | US | disclosed |
| US-5102881-A | Leukotriene biosynthesis inhibitor | MERCK FROSST CANADA, INC. (CA) | 1992-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180370996-A1 | FLUORIDE FLUORESCENCE PROBE | FLNB, AFF4, FGB | ALDH1A1 3319/4885CYP2A6 4120/4885SMN1; SMN2 2030/4885 |
| US-20050240062-A1 | Structural modification of resveratrol: Sodium resverastatin phosphate | PI4KB, HDAC4, PIK3CA | ALDH1A1 3559/4885CYP2A6 3391/4885SMN1; SMN2 4322/4885 |
| US-20090233930-A9 | Novel 2-Amino-Imidazole-4-One Compounds and Their Use in the Manufacture of a Medicament to Be Used in the Treatment of Cognitive Impairment, Alzheimer's Disease, Neurodegeneration and Dementia | PSEN2, MAPT, PSEN1 | ALDH1A1 1372/4885CYP2A6 4046/4885SMN1; SMN2 111/4885 |
| US-10865218-B2 | Fluoride fluorescence probe | FLNB, AFF4, FGB | ALDH1A1 3319/4885CYP2A6 4120/4885SMN1; SMN2 2030/4885 |
| US-20080293718-A1 | Novel 2-Amino-Imidazole-4-One Compounds and Their Use in the Manufacture of a Medicament to Be Used in the Treatment of Cognitive Impairment, Alzheimer's Disease, Neurodegeneration and Dementia | PSEN2, MAPT, PSEN1 | ALDH1A1 1372/4885CYP2A6 4046/4885SMN1; SMN2 111/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.