Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 2/20 | 0.39 |
| ▸ | CSF1R | P07333 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL906091 | 0.84 | CSF1R (0.56) | TSHRHSD17B10CSF1RBRAF | |
| SCHEMBL20862393 | 0.71 | HSD17B10 (0.65) | TSHRHSD17B10CYP3A4CYP2D6SLC6A2 | |
| SCHEMBL10648008 | 0.71 | HSD17B10 (0.51) | TSHRHSD17B10POLBALDH1A1NR4A1 | |
| SCHEMBL18286642 | 0.70 | CSF1R (0.60) | CSF1RBRAFFYN | |
| SCHEMBL13260957 | 0.69 | HSD17B10 (0.58) | TSHRHSD17B10CYP3A4CYP2D6SLC6A2 | |
| SCHEMBL23980124 | 0.67 | PTK2 (0.59) | RAB9ASMN1; SMN2 | |
| SCHEMBL20862426 | 0.66 | HSD17B10 (0.53) | TSHRHSD17B10CYP3A4CYP2D6SLC6A2 | |
| SCHEMBL7877793 | 0.66 | RAB9A (0.57) | TSHRHSD17B10CYP3A4CYP2D6SLC6A2 | |
| SCHEMBL12056805 | 0.65 | CSF1R (0.43) | TSHRSLC6A3POLBRAB9ACSF1R | |
| SCHEMBL10648781 | 0.65 | LMNA (0.47) | TSHRHSD17B10POLBALDH1A1NR4A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7981900-B2 | Modulation microtubules diseases; antiproliferative agents; antiinflamamtory agents | YM BIOSCIENCES AUSTRALIA PTY LTD (AU) | 2011-07-19 | — | — | US | disclosed |
| US-20080194583-A1 | Tubulin Inhibitors | YM BIOSCIENCES AUSTRALIA PTY LTD | 2008-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194583-A1 | Tubulin Inhibitors | TUBB1, TUBB3, TUBA1C | TSHR 4204/4885HSD17B10 2544/4885CYP3A4 4395/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.