Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | HMOX2 | P30519 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | EDNRB | P24530 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MC4R | P32245 | 1/20 | 0.43 |
| ▸ | MC3R | P41968 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1383474 | 0.88 | CYP2C19 (0.67) | CYP2C19SLC6A3LMNASMN1; SMN2CYP1A2 | |
| Hydrochloric Acid SCHEMBL29096814 | 0.86 | CYP2C19 (0.65) | CYP2C19SLC6A3LMNASMN1; SMN2CYP1A2 | |
| Hydrochloric Acid SCHEMBL5011439 | 0.86 | CYP2C19 (0.65) | CYP2C19SLC6A3LMNASMN1; SMN2CYP1A2 | |
| SCHEMBL170301 | 0.85 | SLC6A2 (0.55) | CYP2C19SLC6A3SLC6A2SLC6A4LMNA | |
| Hydrochloric Acid SCHEMBL128794 | 0.83 | SLC6A2 (0.53) | CYP2C19SLC6A3SLC6A2SLC6A4LMNA | |
| SCHEMBL18873534 | 0.83 | CYP2C19 (0.50) | CYP2C19SLC6A3LMNAHMOX2SMN1; SMN2 | |
| SCHEMBL28682706 | 0.82 | CYP2C19 (0.53) | CYP2C19SLC6A3LMNAHMOX2SMN1; SMN2 | |
| SCHEMBL8674258 | 0.81 | SLC6A3 (0.52) | SLC6A3SLC6A2SLC6A4LMNAEPHX2 | |
| SCHEMBL8672694 | 0.81 | SLC6A2 (0.52) | CYP2C19SLC6A3SLC6A2SLC6A4LMNA | |
| SCHEMBL17591689 | 0.80 | LMNA (0.54) | CYP2C19SLC6A3SLC6A2SLC6A4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110166132-A1 | Gamma Secretase Modulators | AMGEN INC. (US) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166132-A1 | Gamma Secretase Modulators | BACE1, BACE2, PSEN1 | CYP2C19 4369/4885SLC6A3 4662/4885SLC6A2 4618/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.