Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.33 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22040148 | 0.77 | NR1H2 (0.35) | NR1H2 | |
| SCHEMBL22040124 | 0.70 | EP300 (0.43) | — | |
| SCHEMBL23891703 | 0.69 | NR1H2 (0.40) | NR1H2PLA2G10PLA2G5 | |
| SCHEMBL22040902 | 0.67 | HDAC6 (0.33) | HDAC6 | |
| SCHEMBL23891672 | 0.67 | CCKBR (0.34) | ALDH1A1 | |
| SCHEMBL17605850 | 0.66 | EP300 (0.43) | NR1H2 | |
| SCHEMBL17605847 | 0.66 | EP300 (0.43) | NR1H2 | |
| SCHEMBL22040127 | 0.66 | EP300 (0.43) | NR1H2 | |
| SCHEMBL22039456 | 0.65 | BACE1 (0.38) | ALDH1A1 | |
| SCHEMBL24349905 | 0.64 | EP300 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020108500-A1 | HISTONE ACETYLASE P300 INHIBITOR AND USE THEREOF | 成都海创药业有限公司 | 2020-06-04 | — | — | WO | disclosed |