Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D | O15399 | 1/20 | 0.46 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.46 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | PRCP | P42785 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.46 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 4/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13333834 | 0.88 | SIGMAR1 (0.57) | GRIN2DGRIN3BCYP2B6SLC6A2SLC6A4 | |
| SCHEMBL2202714 | 0.85 | GRIN1 (0.62) | GRIN2DGRIN3BCYP2B6SLC6A2SLC6A4 | |
| SCHEMBL17438515 | 0.80 | SIGMAR1 (0.54) | GRIN2DGRIN3BCYP2B6SLC6A2SLC6A4 | |
| SCHEMBL2201445 | 0.79 | SIGMAR1 (0.53) | GRIN2DGRIN3BCYP2B6SLC6A2SLC6A4 | |
| SCHEMBL2335867 | 0.76 | GRIN1 (0.70) | GRIN2DGRIN3BCYP2B6SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL2333446 | 0.75 | OPRM1 (0.71) | GRIN2DGRIN3BCYP2B6SLC6A2SLC6A4 | |
| SCHEMBL6023084 | 0.75 | GRIN1 (0.73) | GRIN2DGRIN3BCYP2B6SLC6A2SLC6A4 | |
| SCHEMBL2204527 | 0.74 | SIGMAR1 (0.38) | GRIN2DGRIN3BCYP2B6SLC6A2SLC6A4 | |
| SCHEMBL2201407 | 0.74 | TSHR (0.45) | GRIN2DGRIN3BCYP2B6SLC6A2SLC6A4 | |
| SCHEMBL30364176 | 0.74 | SIGMAR1 (0.77) | GRIN2DGRIN3BCYP2B6SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8278319-B2 | Substituted spiroamine compounds | GRUENENTHAL GMBH (DE) | 2012-10-02 | — | — | US | disclosed |
| EP-2344457-A1 | SUBSTITUTED SPIROAMINES | Grünenthal GmbH (DE) | 2011-07-20 | — | — | EP | disclosed |
| US-20100113417-A1 | Substituted Spiroamine Compounds | GRUENENTHAL GMBH (DE) | 2010-05-06 | — | — | US | disclosed |
| WO-2010049146-A1 | SUBSTITUTED SPIROAMINES | Grünenthal GmbH (DE) | 2010-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113417-A1 | Substituted Spiroamine Compounds | BDKRB1, BDKRB2, REN | GRIN2D 1330/4885GRIN3B 930/4885CYP2B6 1379/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.