Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12772414 | 0.82 | HRH3 (0.42) | HRH3RECQLALDH1A1 | |
| SCHEMBL18032442 | 0.82 | HRH3 (0.39) | HRH3SMN1; SMN2RECQLALDH1A1 | |
| SCHEMBL22304541 | 0.82 | TRPV6 (0.37) | KMT2AALDH1A1 | |
| SCHEMBL18591795 | 0.81 | SIGMAR1 (0.34) | KMT2AHRH3SMN1; SMN2RECQLALDH1A1 | |
| SCHEMBL13656169 | 0.81 | HRH3 (0.44) | HRH3RECQLALDH1A1 | |
| SCHEMBL23334402 | 0.79 | ALDH1A1 (0.37) | KMT2AHRH3SMN1; SMN2ALDH1A1 | |
| SCHEMBL20805308 | 0.79 | HRH3 (0.35) | KMT2AHRH3 | |
| SCHEMBL18551162 | 0.79 | KMT2A (0.50) | KMT2ASMN1; SMN2RECQL | |
| SCHEMBL18177837 | 0.79 | SIGMAR1 (0.41) | KMT2AALDH1A1 | |
| SCHEMBL15696998 | 0.79 | SIGMAR1 (0.38) | KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3660004-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR | Arvinas Operations, Inc. (US) | 2020-06-03 | — | — | EP | disclosed |