Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | APLNR | P35414 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21156890 | 0.81 | KMT2A (0.38) | MEN1KMT2APOLBL3MBTL1 | |
| SCHEMBL19980301 | 0.81 | CCR5 (0.33) | POLBMAPK1 | |
| SCHEMBL22710291 | 0.78 | APLNR (0.38) | MEN1KMT2AHTR2AAPLNRPOLB | |
| SCHEMBL19980286 | 0.78 | APLNR (0.38) | MEN1KMT2AHTR2AAPLNRPOLB | |
| SCHEMBL19980300 | 0.77 | SLC6A2 (0.40) | MEN1KMT2AAOC3TAAR1MAPT | |
| SCHEMBL11313429 | 0.74 | APLNR (0.42) | AOC3HTR2AAPLNRPOLB | |
| SCHEMBL27486417 | 0.73 | HTT (0.53) | MEN1KMT2AAOC3POLBTAAR1 | |
| SCHEMBL20344529 | 0.72 | KMT2A (0.41) | MEN1KMT2APOLBMAPK1L3MBTL1 | |
| SCHEMBL9687675 | 0.70 | POLB (0.56) | MEN1KMT2APOLB | |
| SCHEMBL23671881 | 0.70 | APLNR (0.41) | AOC3HTR2AAPLNRPOLBADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3342771-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-11-25 | — | — | EP | disclosed |
| EP-3375780-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-06-03 | — | — | EP | disclosed |