SCHEMBL22048869

SCHEMBL22048869

CCN1CCc2c1ccc1[nH]c(C(=O)N3CCc4c3ccc3[nH]c(C(=O)O)cc43)cc21

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPKAPK2 P49137 1/20 0.39
RAB9A P51151 4/20 0.39
POLB P06746 3/20 0.39
NPC1 O15118 4/20 0.38
KMT2A Q03164 3/20 0.38
MEN1 O00255 2/20 0.38
RXFP1 Q9HBX9 1/20 0.38
ALDH1A1 P00352 3/20 0.36
HSD17B10 Q99714 3/20 0.36
KDM4E B2RXH2 2/20 0.36
LMNA P02545 1/20 0.36
HRH4 Q9H3N8 4/20 0.35
GAA P10253 1/20 0.35
HPGD P15428 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
PARP1 P09874 1/20 0.35
MAPT P10636 2/20 0.35
ALOX15 P16050 1/20 0.34
MAPK1 P28482 1/20 0.34
TP53 P04637 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20764331 0.86 NOTUM (0.44) RAB9APOLBNPC1KMT2AMEN1
SCHEMBL13183210 0.85 RAB9A (0.41) MAPKAPK2RAB9APOLBNPC1KMT2A
SCHEMBL889826 0.84 KMT2A (0.40) RAB9APOLBNPC1KMT2AMEN1
SCHEMBL532721 0.80 NPC1 (0.38) MAPKAPK2RAB9APOLBNPC1KMT2A
SCHEMBL5384431 0.80 NPC1 (0.38) MAPKAPK2RAB9APOLBNPC1KMT2A
SCHEMBL20764181 0.80 HRH4 (0.50) RAB9ANPC1KMT2AMEN1RXFP1
SCHEMBL14156402 0.79 HSD17B10 (0.43) POLBKMT2AMEN1ALDH1A1HSD17B10
SCHEMBL887712 0.79 KDM4E (0.43) MAPKAPK2POLBKMT2AMEN1ALDH1A1
SCHEMBL12901870 0.78 NOTUM (0.45) RAB9APOLBNPC1KMT2AMEN1
SCHEMBL18165247 0.78 PLG (0.40) RAB9APOLBNPC1KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10890529-B2 Duplex stabilizing fluorescence quenchers for nucleic acid probes ELITECHGROUP, INC. (US) 2021-01-12 US disclosed
US-20200173924-A1 DUPLEX STABILIZING FLUORESCENCE QUENCHERS FOR NUCLEIC ACID PROBES ELITECHGROUP, INC. (US) 2020-06-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200173924-A1 DUPLEX STABILIZING FLUORESCENCE QUENCHERS FOR NUCLEIC ACID PROBES DDB1, DUT, DCLRE1B MAPKAPK2 3403/4885RAB9A 4274/4885POLB 264/4885
US-10890529-B2 Duplex stabilizing fluorescence quenchers for nucleic acid probes DDB1, DUT, DCLRE1B MAPKAPK2 3403/4885RAB9A 4274/4885POLB 264/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.