Sugi Predict

Sugi Predict / Compounds / SCHEMBL5384431

SCHEMBL5384431

SCHEMBL5384431

O=C(O)c1cc2c3c(ccc2[nH]1)N(C(=O)c1cc2c4c(ccc2[nH]1)NCC4)CC3

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NPC1 O15118 3/20 0.38
▸ RAB9A P51151 3/20 0.38
▸ KMT2A Q03164 3/20 0.38
▸ MEN1 O00255 2/20 0.38
▸ RXFP1 Q9HBX9 1/20 0.38
▸ POLB P06746 1/20 0.37
▸ KDM4E B2RXH2 2/20 0.36
▸ ALDH1A1 P00352 2/20 0.36
▸ LMNA P02545 2/20 0.36
▸ HSD17B10 Q99714 1/20 0.36
▸ KDM4C Q9H3R0 1/20 0.35
▸ PLK4 O00444 1/20 0.35
▸ DAPK3 O43293 1/20 0.35
▸ DYRK3 O43781 1/20 0.35
▸ JAK2 O60674 1/20 0.35
▸ PRKD3 O94806 1/20 0.35
▸ MAP4K4 O95819 1/20 0.35
▸ PIM1 P11309 1/20 0.35
▸ RPS6KB1 P23443 1/20 0.35
▸ CDK2 P24941 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL532721 1.00 NPC1 (0.38) NPC1RAB9AKMT2AMEN1RXFP1
SCHEMBL22048825 0.90 RAB9A (0.38) NPC1RAB9AKMT2AMEN1RXFP1
SCHEMBL22062300 0.89 PLK4 (0.38) NPC1RAB9AKMT2AMEN1RXFP1
SCHEMBL29462567 0.89 NPC1 (0.36) NPC1RAB9AKMT2AMEN1RXFP1
SCHEMBL20764391 0.88 NPC1 (0.35) NPC1RAB9AKMT2AMEN1RXFP1
SCHEMBL5388939 0.88 RAB9A (0.41) NPC1RAB9AKMT2AMEN1RXFP1
SCHEMBL22871731 0.87 PLK4 (0.38) NPC1RAB9AKMT2AMEN1RXFP1
SCHEMBL7594289 0.85 HRH4 (0.34) NPC1RAB9AKMT2AMEN1RXFP1
SCHEMBL124755 0.85 KDM4E (0.48) KMT2AMEN1KDM4EALDH1A1LMNA
SCHEMBL20764331 0.84 NOTUM (0.44) NPC1RAB9AKMT2AMEN1RXFP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7297495-B2 Hybridization-triggered fluorescent detection of nucleic acids EPOCH BIOSCIENCES, INC. (US) 2007-11-20 — — US disclosed
US-20070166723-A1 Hybridization-triggered fluorescent detection of nucleic acids EPOCH BIOSCIENCES INC. (US) 2007-07-19 — — US disclosed
US-6951930-B2 Hybridization-triggered fluorescent detection of nucleic acids EPOCH BIOSCIENCES, INC. (US) 2005-10-04 — — US disclosed
US-20030113765-A1 Hybridization-triggered fluorescent detection of nucleic acids EPOCH BIOSCIENCES, INC. (US) 2003-06-19 — — US disclosed
US-6472153-B1 COVALENTLY BOUND OLIGONUCLEOTIDE/MINOR GROOVE BINDER/LATENT FLUOROPHORE COMBINATION EPOCH BIOSCIENCES, INC. 2002-10-29 — — US disclosed
EP-1224332-A1 HYBRIDIZATION-TRIGGERED FLUORESCENT DETECTION OF NUCLEIC ACIDS Epoch Biosciences, Inc. (US) 2002-07-24 — — EP disclosed
WO-2001031063-A1 HYBRIDIZATION-TRIGGERED FLUORESCENT DETECTION OF NUCLEIC ACIDS EPOCH BIOSCIENCES, INC. (US) 2001-05-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070166723-A1 Hybridization-triggered fluorescent detection of nucleic acids DDX21, RNGTT, NOP2 NPC1 2391/4885RAB9A 4224/4885KMT2A 3428/4885
US-20030113765-A1 Hybridization-triggered fluorescent detection of nucleic acids DDX21, RNGTT, NOP2 NPC1 2391/4885RAB9A 4224/4885KMT2A 3428/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.