Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 3/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.32 |
| ▸ | CDK2 | P24941 | 3/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.32 |
| ▸ | DBF4 | Q9UBU7 | 3/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22061420 | 0.72 | CDC7 (0.32) | KDM4ECDC7CCNE1CDK2ROCK1 | |
| SCHEMBL22061498 | 0.69 | MKNK1 (0.46) | — | |
| SCHEMBL17407299 | 0.67 | CES1 (0.48) | CDK2 | |
| SCHEMBL29361608 | 0.65 | TDP2 (0.35) | KDM4E | |
| SCHEMBL14991726 | 0.65 | TDP2 (0.35) | KDM4E | |
| SCHEMBL24311518 | 0.65 | PPOX (0.33) | CDK2 | |
| SCHEMBL22061567 | 0.63 | PRKCA (0.36) | — | |
| SCHEMBL2074537 | 0.61 | MAPK14 (0.41) | — | |
| SCHEMBL12525012 | 0.61 | MAPT (0.33) | CDK2 | |
| SCHEMBL11981424 | 0.61 | KDM4E (0.67) | KDM4EGLACDC7CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020108619-A1 | MNK INHIBITOR | 上海迪诺医药科技有限公司 | 2020-06-04 | — | — | WO | disclosed |