Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CCR1 | P32246 | 1/20 | 0.44 |
| ▸ | CCR8 | P51685 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11730085 | 0.81 | CCR1 (0.52) | MAPTLMNAHTTCCR1CCR8 | |
| SCHEMBL10647459 | 0.80 | NR1H2 (0.46) | MAPTLMNAHTTCCR1CCR8 | |
| SCHEMBL2964870 | 0.77 | — | — | |
| SCHEMBL25256773 | 0.75 | ALDH1A1 (0.42) | MAPTLMNAHTTGRM5RAB9A | |
| SCHEMBL22561744 | 0.73 | — | — | |
| SCHEMBL25219245 | 0.71 | KDM4E (0.48) | MAPTLMNAHTTMEN1KMT2A | |
| SCHEMBL11728692 | 0.71 | CCR1 (0.46) | MAPTLMNAHTTCCR1CCR8 | |
| SCHEMBL10647452 | 0.71 | LMNA (0.44) | MAPTLMNAHTTCCR1CCR8 | |
| SCHEMBL27529897 | 0.71 | NOTUM (0.47) | MAPTLMNAHTTCCR1CCR8 | |
| SCHEMBL2616100 | 0.70 | CCR1 (0.44) | MAPTLMNAHTTCCR1CCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4212513-A1 | 1,3,5-TRIS(6-METHYLPYRIDIN-2-YLOXY)BENZENE DERIVATIVES AND RELATED COMPOUNDS AS NLRX1 LIGANDS FOR TREATING INFLAMMATORY DISEASES | LANDOS BIOPHARMA, INC. (US) | 2023-07-19 | — | — | EP | disclosed |
| US-20210309610-A1 | NLRX1 LIGANDS | LANDOS BIOPHARMA, INC. (US) | 2021-10-07 | — | — | US | disclosed |
| US-11066364-B2 | NLRX1 ligands | LANDOS BIOPHARMA, INC. (US) | 2021-07-20 | — | — | US | disclosed |
| US-20200255378-A1 | NLRX1 LIGANDS | LANDOS BIOPHARMA, INC. (US) | 2020-08-13 | — | — | US | disclosed |
| US-10676436-B2 | NLRX1 ligands | LANDOS BIOPHARMA, INC. (US) | 2020-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210309610-A1 | NLRX1 LIGANDS | NLRP1, NLRP3, NOD1 | MAPT 2336/4885LMNA 3512/4885HTT 2535/4885 |
| US-20200255378-A1 | NLRX1 LIGANDS | NLRP1, NLRP3, NOD1 | MAPT 2336/4885LMNA 3512/4885HTT 2535/4885 |
| US-11066364-B2 | NLRX1 ligands | NLRP1, NLRP3, NOD1 | MAPT 2336/4885LMNA 3512/4885HTT 2535/4885 |
| US-10676436-B2 | NLRX1 ligands | NLRP1, NLRP3, NOD1 | MAPT 2336/4885LMNA 3512/4885HTT 2535/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.